Tag Archives: clinical research careers

What Are the Steps Related to Clinical Assessments?

Clinical assessments are a type of analysis that involve huge numbers of individuals order to test new therapies. Many, but not all analysis, are assessments.

Clinical analysis aim to find out important info in response to any adverse wellness question in a very methodical way. A well designed analysis will provide efficient evidence that can help improve NHS services and therapies and the healthcare understanding of doctors.

To be efficient it usually involves obtaining wellness details from a variety of individuals whose healthcare concerns fit the topic of the study. Where sufferers agree, or “consent”, to join as volunteers, this details might be obtained by:

  • Interviews
  • Questionnaires
  • Tests on sufferers in a healthcare setting that measure the effects of new drugs
  • Using individual records
  • A combination of the above

If you are interested in becoming a individual in research:

You could ask your GP or Advisor to consider any assessments or analysis that you may be suitable for You could check out the web pages for your local Clinical Research Network

You could check out the The UK Clinical Trials Entrance which provides details about scientific analysis assessments running in the UK

The NHS Structure says that your NHS healthcare professional should inform you of any analysis for which you may be eligible. ‘Eligible’ here concerns how you fit the strict healthcare and personal requirements used in the study design for it to work technically.

Think about it for a time that you are a effective psycho therapist. Cynthia comes to see you because she’s having a problem. How do you cure her? How do you even know incorrect with her?

Clinical assessment is a way of identifying and preparing treatment for a individual that includes analyzing someone in order to determine incorrect. There are several kinds of emotional tests, all of which have their own pros and cons.

What’s the point of assessment? To response that, let’s go back to the time that Cynthia walking into your workplace. She informs you that she’s sensation very pressured out and nervous because she keeps failing to remember factors. She used to be really up to the mark, but lately she has problems keeping in mind where she sitting her car or what she did just a couple of moments ago.

What’s incorrect with Cynthia? There are several factors that can cause forgetfulness. The only way that you can find out incorrect with her is to do some kind of assessment. Medical tests help you, the psycho therapist, to know what might be resulting in trouble for your individual. Clinical assessment example can be related to psychology.

Related Topics:

1)Requirement of Clinical Research Associate

2)What is the responsibility of a clinical research associate?

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First in Human (FIH) Clinical Trials

First in Human (FIH) Clinical Trials

First this first, you must know what FIH is as all FIH trials are not the same. FIH trials are basically conducted with 20-80 study volunteers. The objective is to find the metabolism and pharmacologic action of a test drug in humans, the side effects that might be associated with increasing doses, and if possible gain early evidence on effectiveness.

In simple terms, FIH studies give researchers a base to understand the safety of the drug and might also show the action mechanism in humans.

Not an easy job

Nothing is so easy, there is Phase I studies that deviate from the FIH Phase I cookie-cutter norm, such as:

  • Clinical trials in which volunteers receive one of the following types of test drugs:
    1. A new compound in a novel drug class

    2. A novel compound in a drug class that is being through human testing with a different IND

    3. A novel drug/approved drug combo

    4. An approved drug with a novel formulation or changed dose

  • Clinical research requires a special population of age or type.
  • Clinical trials for which the drug is therapeutic

Each FIH trial should be evaluated on an individual basis because the objectives and risk factors vary. The preclinical data, trial design, proposed population, and safety measures must be evaluated for every FIH trial.

What part does the CRO play?

The CRO plays a vital role. They are to offer their expertise to make sure the successful completion of the clinical trial.  

CROs experienced in the conduct of FIH studies are knowledgeable and equipped to guide sponsors through the process of designing the best possible protocol. They conduct studies for the whole day, starting from Monday to Sunday. They would tell you about recruitment, if your blood draw times are feasible, and if your timelines are realistic.

A team with general or late phase clinical research expertise is not sufficient.

It is essential that the Chief Investigator and the study team have a lot of experience conducting FIH trials and possess the qualifications to make sure that the trials go smoothly. The clinical team is vital in ensuring that the protocol is optimal with little scope for amendments or deviation, while also making sure recruitment goals can be met, even with the most strict inclusion/exclusion criteria. Whether it’s a simple Single Ascending Dose (SAD) trial or a complex, adaptive design, the team conducting the study is a pivotal factor to success.

When it’s time to outsource a clinical trial to a CRO, it’s best to find out how involved the principal investigator (PI) and sub-investigators will be. Moreover, the experience of project managers, study coordinators, lab personnel, data managers, and medical writers are equally important. The PI is responsible for supervising the staff; however, problems can arise when a PI is either an inexperienced or uninformed in conducting FIH trials or puts too much responsibility on the staff to perform tasks that the PI should be overseeing.

In short, an experienced CRO can minimize the risk of recruitment and retention issues look after the safety concerns, bad data and a whole list of other issues that could halt your FIH clinical trial.

Does your CRO have what it takes?

You need to look into the matters discussed above and have your words with your consultant to know hoe efficient your CRO is.

We conclude the discussion here.

In the competition of many organizations CRB Tech Solutions developed a good name. It has earned a name in offering the best training in Clinical Research.

Clinical research jobs in Pune are increasing and to meet the current requirement of the proficient candidates, you should consider enhancing yourself with our clinical research training program.

The Clinical Research review by CRB Tech Solutions will guide you in considering a clinical research career in this field.

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How To become A Clinical Research Scientist?

How To become A Clinical Research Scientist?

Clinical Research Review presents the road map to become a clinical research scientist. This would help those who wants to make a career in clinical research.

Clinical research scientists does medical research for the welfare of health in humans and/or animals. Clinical research trials are one of their methods of investigation. Here is a chart giving an overview of how to enter this sector:

Degree MD &/or PhD degree
Field of Study MD: medicine
PhD: biology
Responsibilities Laboratory research & analysis for medical innovations; publication of research

Basic Education For A Clinical Research Scientist

There are various educational paths to become a clinical research scientist. Many clinical researchers have medical degrees, doctorates in a natural science or both. One can begin the pursuit of this career with a regular bachelor’s degree. A course of study in or related to the field of life science is highly recommended. The coursework in this area should include general biology, mathematics, physics and more specialized topics such as cell biology. Medical and doctoral programs are highly selective, so a strong academic record is desirable.

An Advanced Degree Program in Science or Medicine

Most clinical research scientist positions require either an advanced degree in the biological sciences or a medical degree. Graduate degree programs in cellular and molecular biology, neuroscience, biochemistry or microbiology often satisfy this need. Some universities offer master’s degree programs in clinical research. Alternatively, obtaining a Medical Doctor (M.D.) or nursing degree may qualify individuals to work in the field.

The success tips is that consider attaining a dual degree. Many clinical research scientists choose to complete a dual degree program with majors in science and medicine. In fact, some job postings require that candidates possess dual degrees. Students in these dual degree programs learn about medical practices and advanced research methodologies. Possessing two graduate degrees may make students eligible for more job positions after graduation.

Work as a Clinical Research Associate

The clinical research scientists typically begin their careers in fresher positions, possibly as a clinical research associate. These associates assist research scientists in designing and carrying clinical trials. They also help validate gathered data and monitor the procedures to assure that the process complies with professional protocol. The success tip is earn a certificate like the Certified Clinical Research Associate, Certified Clinical Research Coordinator and Physician Investigator. Earning any of these certifications requires clearing an exam. These certifications are recognized in the industry as indicating various job skills and, may help individuals advance in their careers.

Work as a Clinical Research Scientist

Clinical research scientists can work at universities, pharma companies, clinical research organizations, hospitals or for the government. These scientists perform analysis on cells, tissue and organs to identify microbes and toxins with the goal of understanding the reason of diseases and being able to develop vaccines or medicines for treatment. Some clinical research scientists may work directly with patients in health care centers by administering clinical trial drugs and therapies.

Research scientists have chances to advance to supervisory or lead positions with enough experience and strong performance.

The Success tip is to Participate in continuing education. Knowledge in scientific fields changes rapidly. Clinical research scientists may find it advantageous to participate in continuing education courses offered by professional organization. Such professional training may come in the form of conferences, webinars, online classes or in-person courses.

In the race of many institutes CRB Tech Solutions has it own name in offering Clinical Training.

Clinical Research review by CRB Solutions is enough to make you consider and take up a career in this field.

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Clinical Research Industry’s Strategy to Epidemics

Clinical Research Industry’s Strategy to Epidemics

In the field of clinical research mainly epidemic response face many challenges. Clinical research done on global health concerns often needs rapid action, immediate trial start-up and lower standard good clinical practice (GCP), among many other struggles. It’s very difficult to carry out a clinical trial during the course of an epidemic. However, there are measures to overcome these challenges.

In a recent conference of Partnerships in Clinical Trials (PCT) that was held as a part of Boston Biotech Week (BWB), two inspiring presenters shared their story of journeys working to combat infectious diseases, like Ebola and Zika, in 3rd world countries. Both the presenters presented a common idea that the research industry needs to work together to become more prepared for responding an epidemic occurrence of an outbreak.

Collection of right data

Presenter Toni Hoover of Bill & Melinda Gates Foundation said on the power of technology and therapeutic innovations to fight diseases that affects underprivileged individuals. She said that their organization is dedicated to enhancing quality of life worldwide, works with many people to give vaccines and new therapies to people in poor and downtroden communities.

The Foundation and its collaborators in the biotech field are working to collect data required to make informed decisions during an epidemic. Hoover said that the data has the potential to be utilised to predict where the next epidemic might occur, pronouncing that the whole healthcare ecosystem needs to work together to prepare and develop a platform for combatting with epidemics like that of Ebola and Zika. She said that Zika is a perfect example that says the need to think about interventions, but also how preparations can be made with the help of collection of the right data to advice decisions.

Industry transparency must be increased

In the same manner, presenter Trudie Lang of the Global Health Network at the University of Oxford expressed her belief that the clinical research industry must be more prepared to respond in the event of an outbreak.

With reference, Lang shared her experience as a researcher performing an Ebola trial in West Africa. She described the hurry to begin the study and was under immense pressure to complete the trial in 16 week only. Lang said that her team was able to complete the clinical trial at rapid speed, but admitted they were too late. The epidemic already spread fast by the time the trial was complete.

This experience made Lang realise that the research community must be always ready to combat infectious diseases before an epidemic reaches a downward slope, more possibly before an outbreak occurs.

Finally Lang proposed a solution to the current problem by saying that research information must be shared and there should be transparency in clinical research industry.Lang came forward with an argument that sharing clinical research information between groups, plagued areas and regions would enhance the agility of a research enabling faster response to life-threatening diseases.

Fact is that epidemics and global diseases are significan cases for the need of organizational collaboration and information sharing. The two women and their research highlighted many aspects of clinical research that could prevent or help people in their suffering worldwide.

Now we conclude the discussion.

To learn more methods for increased industry efficiency, view our library of resources for clinical research professionals.

In the competition of many organizations CRB Tech Solutions developed a good name. It has earned a name in offering the best training in Clinical Research.

Clinical research jobs in Pune are increasing and to meet the current requirement of the proficient candidates, you should consider enhancing yourself with our clinical research training program.

The Clinical Research review by CRB Tech Solutions will help and support you in considering a clinical research career in this field.

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21 Trends for Nurse Practitioners in 2016 Part III

21 Trends for Nurse Practitioners in 2016 Part III

Today we continue with this blog topic we started and conclude the discussion that we started a few days back, what is making nurse practitioners trending in 2016.

Population Health

The term maninly includes geographic populations such as communities or countries but could also be ethnic groups. The actual goal of population health initiatives is to understand that every group has a unique need and create target friendly interventions to look into the needs. If reports are to believe then this collaboration is really being fruitful and significant.dicalechnolog

Electronic Medical Records (EMR)

A report stated that by December 2015, the EMR market was estimated to be worth $23 billion with more than 400 unique vendors. The report made the top earning EMR companies happy,but clinicians were not.

In 2016, the EMR market players might shrink. With the need of smaller medical practices those practices will take upon the larger organization’s EMR. This attempt by healthcare groups will gradually squeeze out smaller EMR vendors, and the market will incline more towards the EMR giants like Epic and Cerner.

Mobile Health(mHealth)

mHealth is a rising trend currently in health sector. Sometimes called connected health, it is defined as the generation, aggregation, and dissemination of health information via mobile devices.Other trends in the mobile health market include anthe alternate utility of helpful smartphone apps. To mention, health and fitness apps grew 87% faster than the overall app industry in 2014. This rise has attracted major technology companies like Apple and Google to introduce their own mobile health products.

The Cloud

As per an international survey, 83% of healthcare officials are currently using cloud services for human resources applications,clinical information and disaster recovery. Practically cloud-based softwares in healthcare lessen the costs by limiting number of servers a hospital needs to purchase.

A huge challenge in clinical trials has been data storage and currently, 30% of the world’s computer capacity is used to archive medical images including CT scans, x-rays and angiograms. Cloud helps maintain data with an exponential capacity throughout the entire lives.

Telemedicine

Currently with an attempt of digitalization and increased public access to WiFi, and a essence of connectivity, telemedicine is fast emerging another booming industry in healthcare technology. Repots suggest that telemedicine is safe and cost effective.

Ingestibles, Implantables, & Sensors

In the years 2014 and 2015 health technology wearables made rounds in headlines, and this year it took to more about ingestibles, implantables, and sensors. Google recently announced their smart contact lenses that can monitors a wearer’s blood sugar levels in real time.

Decision Support

Yes we shall mention aboyt IBM’s Watson, named after the company’s first CEO, it is a highly intelligent computer capable of answering complex questions using natural language processing. It is to believe that the future for Watson Health is bright.

The Internet of Things

As it relates to the healthcare sector, it attracted a lot of attention in 2015 when Market Research reported and predicted that this industry would be worth $117 billion by 2020. Abbreviated as IoT, is said to have all objects connected and collects data. The value of IoT can be ascertained from the correlation between all the things and the data created by them.

The IoT helps nurse practitioners to allow theirs patient’s to recover at home yet keeping a watch ober them and monitoring their health status from a distance making use of products like BodyGuardian Remote Monitoring System.

Now we conclude here. Hope the discussion is giving the right and precise information to you.

Stay connected with us for more discussions to come. Let us know your experience with us in the comment sections below.

In the competition of many organizations CRB Tech Solutions developed a good name. It has earned a name in providing the best training in Clinical Research.

Clinical research jobs in Pune are increasing and to meet the current demand of the proficient candidates, you should consider enhancing yourself with our clinical research training program.

The Clinical Research review by CRB Tech Solutions will guide you in considering a clinical research career in this field.

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What To Do When An Outsourced Clinical Trial face A Crisis

What To Do When An Outsourced Clinical Trial face A Crisis

Today in this blog topic we would discuss outsourcing in clinical research and how to find a solution if an outsourced clinical trial hits a roadblock.

In the 1990s and 2000s, outsourcing already revolutionized the IT industry and experts have a belief that outsourcing has the power to revolutionize scientific research in the very same way. But under present situation, outsourcing in science is very difficult. It’s hard to find providers and is hard convincing them and also difficult to evaluate them and pay them. Well other industries solved these barriers by creating a marketplace, but the question is whether same solution is applicable to scientific researchers also?

Well Science Exchange can make makes outsourcing easy and wondering how many more discoveries can be made when scientists will be able to tap into the best resources. A very exciting thought!

But the fact is that keeping clinical trials on schedule is not an easy task. Whether a sponsor face issues with timeline, quality, personal or plenty of other things with an outsourced partner, it’s critical to address the problems as soon they arise. You are right we are making mention about the barriers that can be faced in clinical outsourcing.

When a clinical study hits a roadblock, there are a few options that can be addressed. One choice is to have a 3rd party interference, evaluate the situation, and oversee the original partner until study completes. Another option is that a 3rd party rescue where the study is taken over completely.

But while you take the decision about which option you should go for that would be best for your company, consider the following:

  • How fast does the database lock need to occur? If the DB Lock date has some good time remaining, it could be best to have a 3rd party come to the rescue. But, if only a couple of weeks are left, transferring the study is probably not a good idea; this might push away the timelines out even further and increase costs. In such situation, the best solution might be to let the study be where it is, but get a 3rd party come in and take the charge.
  • Who possess the database? If your database is with the organization which initially contracted to conduct the study then moving it to another company could pose a significant challenge, as that alone needs more time and money. But if your study is being carried out by a company provides study and rescue operation, handing the task to them is often the wisest decision.

It is quite obvious that a sponsor choose a partner seeing on the monetary aspect and if the partner fails to keep the words! Over the years, two key lessons surfaced about outsourcing: (1) Need to give extra attention to the data quality produced by the partner, and (2) never accept words that appears very true and too good.

So keep the above mentioned points in mind while selecting your outsource partners, and there will be better chances of avoiding barriers in your research study.

We conclude here. Hope you liked the discussion let us know your opinion in the comment section below.

In the competition of many organizations CRB Tech Solutions developed a good name. It has earned a name in offering the best training in Clinical Research.

Clinical research jobs in Pune are increasing and to meet the current requirement of the proficient candidates, you should consider enhancing yourself with our clinical research training program.

The Clinical Research review by CRB Tech Solutions will guide you in considering a clinical research career in this field.

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How Clinical Research Certifications Help Pharma

How Clinical Research Certifications Help Pharma

A non-profit organization, National Board of Medical Examiners (NBME) has been around for about 100 years. Its primary mission is to assess the qualifications of healthcare professionals. Though it’s popularly associated with the U.S. Medical Licensing Exam (USMLE), NBME also has also impacted different healthcare professions, which includes medical assistants, veterinarians and physical therapists. Very recently, the group has been looking into designing an assessment that would be beneficial to clinical researchers.

The researchers conducted by NBME, has a goal to determine their main points and evaluate if there was a need for some type of standardization, especially in the area of training. They assessed there was a need for training, a method to calculate the effectiveness of it, and to lessen redundancy in training that existed.

By the conclusion of their research, NBME developed two certification programs in association with clinical research experts. One for clinical investigators and scientists, while the other is for monitors, associates, and coordinators. The mode of assessments include basic knowledge in clinical research, which includes ethics, study design, manage data and other topics professionals would need to be aware of, irrespective of their role in the clinical trial process. The two certifications vary with respect to specifics of the positions.

In order to apply for the exam and gain certification, the examinees must give their eligibility evidence, including education and experience in clinical research. The multiple answer exam takes 4 hours and 15 minutes to complete.  After the exam, examinees can review information about their performance, including areas of strength and weakness. If an organization makes the exam available to their employees, that organization can receive aggregated information on staff performance so as to identify knowledge areas in need of improvement and improve future training for researchers.

For the CROs and for sites, having this certification in place for researchers ensures staff proficiency and knowledge to current and future partners.AS mentioned, the certification is individual specific hence not portable. Once someone is certified, that certification will enable them wider opportunities. For sponsor companies, the certification ensures that their internal trials are being handled by qualified professionals.

During the start of research they found there were other programs available to clinical researchers which were webinar-based that would grant participants a certificate after completion. Their mission is to create a program that would be effective at determining a researcher’s skill set.

Though there are other clinical certifications available, like SOCRA and ACRP, and have their own certification programs, but they are quite specific to defined titles within the industry.

To conclude, Short notes NBME became aware of the requirement for certifications after the organization of physicians working in clinical trials wanted to ensure proper certification. Upon evaluating those concerns, NBME realized the need for a pathway for individuals to get into research, which involved improving those skills that they need to be successful.

Hope this certification program will delete some of those challenges and make the certification process easier for professional who want to pursue in this field.

In the competition of many organizations CRB Tech Solutions developed a good name. It has earned a name in offering the best training in Clinical Research.

Clinical research jobs in Pune are increasing and to meet the current requirement of the proficient candidates, you should consider enhancing yourself with our clinical research training program.

The Clinical Research review by CRB Tech Solutions will guide you in considering a clinical research career in this field.

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What Does Patients Want from Pharma

What Does Patients Want from Pharma

Time is changing! So also different approaches and methodologies. It’s now time to listen to the patient. And look at the nose. These words were uttered many years ago during a workshop on allergic rhinitis . These deceptively simple words were spoken by Dr Bill Frankland, one of the most distinguished clinicians of the 20th century.

He emphasized on putting the patient experience first. He was of the opinion that listening to the patient was critical to understanding what interventions might be required.

His interest in treating patients like grown-ups was way ahead of its time. Even now, when the patient is speaking, the doctor may not always be listening. The opinion of the patients get filtered.

This is not just a failing of the medical profession. Though the healthcare advocates talk about patient-centricity all the time, but in practice that often remains on paper only.

Now what do you mean by patient perspective? The following is a definitive though not obvious list of patient needs, but it might provide a useful framework for discussion.

1. People and not patients

We don’t want our lives to be defined by illness. We are living beings and not passive objects. We need to live as people and not like patients.

2. High expectations

We desire importantly, even in the face of chronic or acute illness. This says the importance of mental health for a physical health, and vice versa.

3. Holistic wellness

Breaking down the barriers between the providers of education, nutrition, health, exercise, transport and social care and creating a genuinely holistic approach will need a revolution in thinking, but it is the only way to put the person at the center. The role of pharma here will be critical .

4. Rapid diagnosis

This means that the doctor will work out quickly what is wrong with us yet, sadly, and especially in rare diseases, this might not happen. For example, with Fabry disease, a leading UK expert said it can take 10 years and 10 specialists before a diagnosis is made in a child not previously identified as being in a genetically susceptible family. We need a better understanding of the costs of such delays in diagnosis in terms of wasted medical resources,family disruption, time spent and loss of childhood. For the affected individuals these costs are almost incalculable.

5. Sharing the experience

These personal costs depict the need for, and importance of, groups for patients to share their knowledge, provide each other support, speak in a strong voice and be powerful research partners. Even with more common diseases, there is a huge gap between proven best practice and what happens in the field. For instance, it took many years for ACE inhibitors to make way into everyday practice in the management of chronic heart failure and, even today, we struggle to sustain the condition in the face of really clear outcome evidence, leaving patients incapacitated, in the hospital and unable to perform simple acts of daily life.

6. Education

More education is needed at every level, and pharma sector has a big role to play in listening to and informing both physicians and those they treat. Let this knowledge be both evidence-based and respectful.

We conclude here.

In the competition of many organizations CRB Tech Solutions developed a good name. Its well known in providing the best Clinical Research training.

Clinical research jobs in Pune are increasing and to meet the increasing need of the proficient candidates , you should consider enhancing yourself with our clinical research program.

The Clinical Research review by CRB Tech Solutions will guide you in considering a clinical research career in this field.

Related Topics:

1) What is the Career in Clinical Psychology?

2) Know how healthcare education online can transform your career

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Clinical Research For Physiotherapy

Clinical research is quite vital in the field of physiotherapy. Physiotherapists depends on information from researches to enhance the knowledge they have already gained through their university education and with continuous education courses.

Physiotherapists use the method of “evidence-based practice” as the basis for their treatments; based on quality controlled scientific research and clinical reasoning. Clinical research helps the practitioners keep updated with the latest in practice methods. With the knowledge gained from clinical research, the physiotherapists can explain that the methods CR specialists use to treat our patients are based on empirical evidence, peer review and sound clinical reasonings behind every principles.

There is a great deal of clinical research being performed in physiotherapy nowadays as has been the case for many decades. By regularly update of skills and taking on broad new proof based research, physiotherapists are at the cutting edge of developments in the healthcare sector and the physiotherapist have the scientific evidence to support their treatment methods.

As physiotherapists, they treat a wide array of medical conditions :

  • Spinal pain and injuries
  • Headaches
  • Sports injuries
  • Fractures
  • Musculoskeletal problems
  • Post-surgical rehabilitation
  • Biomechanical problems
  • Arthritic conditions
  • Neurological disorders and diseases
  • Cardiothoracic conditions
  • Paediatric conditions

A few to mention!

Physiotherapists are trained in manual therapy which means they are “hands on” with their patients. In addition to their manual skills they sometimes make use of different ways to reduce pain and inflammation including ice, hot packs,TENS, E-stim, laser treatment and ultrasound. Trigger point therapy and acupuncture is widely practiced by physiotherapists. The physiotherapy experts are highly trained in exercise prescription and often give their patients exercises to practice at home to help resolve their conditions.

The profession addresses neurological,orthopedic and cardiopulmonary problems among people of various age range from infants, children, adults and all populations.

Physiotherapy treatment might involve exercise to improve strength,

motion and endurance range and to correct imbalance of posture and muscle , joint mobilization, manipulation and soft tissue massage, as well as stretching and trigger point therapy to reduce stiffness and to relieve pain.

Patients with neurological disorders such as multiple sclerosis, stroke, cerebral palsy, Parkinson’s disease and spinal cord injury that can benefit greatly with physiotherapy methods. Interventions focus on muscle control, recovery of fine and gross motor skills, improve daily function, regaining of strength and flexibility, restoring and improving gait and training in the use of aids of mobility.

Cardiopulmonary conditions respond good to physiotherapy intervention. Patients who have difficulty performing their activities of daily living, or who have problem with shortness of breath and reduced endurance, can achieve improved quality of life through guided training. Intervention includes manual therapy and exercise to help clear congestion in the lungs, counseling about risk factors, patient education to prevent future occurrence and behavior modification. For those patients who have had cardiopulmonary surgery, physiotherapy is initiated at an early stage to prevent the patient from losing strength and function.

So the clinical trials that are ongoing worldwide, would definitely help with many novel techniques that would be more efficient, patient friendly and less time consuming.

Amidst many institutes in Pune, CRB Tech Solutions has created its own niche. Its very popular in giving the best training in Clinical Research. Our clinical research institute has created a name for itself in this field.

Clinical research jobs in Pune are increasing gradually and to meet the emerging need of efficient professionals , you should consider upskill yourself with our clinical courses.

The Clinical Research review by CRB Tech Solutions will help you in considering and taking up a clinical research career in this field.

Related Posts:

1) Clinical Research Organization

2) What is Clinical Research Organization and jobs in a CRO

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A Drought in Antibiotic Discovery

A Drought in Antibiotic Discovery

The year 1928 saw a major medical breakthrough owing to Flemming’s serendipitous discovery of penicillin, which was later claimed as the 20th century miracle drug. But the impact of this discovery was not well understood until the 1940s, when its application as a therapeutic agent was made possible by Florey and Chain.

Blamed for this late realization was the lack of biochemical and microbiological expertise at that time, as well as the lack of interest and support from the scientific community brought about by previous experience with the failure of pyocyanase and the toxicity of Salvarsan.

A-Drought-in-Antibiotic-Discovery

In 1935, a breakthrough that covered the era of antibacterials was made by the German biochemist Gerhard Domagk at the Bayer Laboratories of the I.G. Farben company in Germany. He discovered and developed the first sulfonamide, a synthetic red dye popularly known by its trade name of Prontosil, the first commercially available antibacterial.

The clinical successes resulted in a sharp decline in mortality due to killer diseases such as meningitis, child bed fever and pneumonia. Domagk’s discovery saved many lives, including prominent figures such as Winston Churchill and Franklin D. Roosevelt, Jr., son of then US President Roosevelt.

Inspired by the groundbreaking work of Domagk and Fleming, Florey and Chain, a number of subsequent antimicrobial discoveries quickly followed. Nowadays, newer antimicrobial compounds continue to be discovered and introduced, although the rate has slowed considerably.

According to an analysis done by a known magazine, large pharma companies spend approximately $5 billion to bring one new drug to market. About $350 million of the cost is to bring the drug to market, the rest is the money spent on drugs that fail safety or efficacy clinical trials, thus a pharma company must recoup the billions that they lose on failed drugs by the one drug that makes it to market.

A lot of money spent and pharmaceutical companies recoup more of their money on drugs like antidepressants and anti-inflammatories because they can be used regularly and not lose their effectiveness. That is not the case with antibiotics.

Antibiotics are very costly to develop and they can lose their power to fight infections with time. How? The bacterium that survived and is antibiotic-resistant is the one that begins reproducing in the body, thus the antibiotic originally used is no longer effective and a new antibiotic is needed to fight the mutated bacteria.

In the past five years the FDA has approved two systemic antibiotics. This is a drop of 88% since the mid-1980s.

While the benefits of the GAIN act are great, it seems that there is still a steady decline of new antibiotic development that has worried many institutions and organizations such as the World Health Organization (WHO) which stated that we’re in a competition against time to develop new antibacterials.

The small biotechnology companies are bringing new antibiotics to the market and it appears that the Center for Disease Control is pushing hospitals to enact antibiotic stewardship programs to make sure that such medicines are only used when they are really required. Dr. Tom Frieden of the CDC stated that antibiotic prescription can save patients’ from deadly infections and protect lifesaving remedies for tomorrow’s patients.”

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Related Topics:

1) Pharmacovigilance: Common terms used in drug safety

2) Pharmacovigilance scope

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