Category Archives: Clinical research

A Way Towards Taking Consumer Apps To The Healthcare System

Consumer Apps To The Healthcare System

In the age of biosensors, wearable and remote health monitoring, consumers are downloading apps to keep a track on their health and wellness, which creates a revolution that could lead to big impact and outcomes for patients who looks forward to become an expert of their own health.

A trend which hospital teams are taking note of, collaborating with design leaders to discuss what new application-based solutions could mean for clinicians in a key topical discussion at IDSA’s recent medical conference.

Below, we share top points to consider for those exploring the advantages of integrating consumer health and wellness applications into patient journey and clinical settings.

Note the Variances in Rules and Regulations

It is important to distinguish the differences between what makes an app ready for adoption with a purely consumer market vs a clinical one.

In a medical setting, clinicians might need more out of the app to justify its use and integration into the workplace. This could shift the intended app output, and shift the app functionality in ways that need to be addressed as something new.

To remove the guesswork, the Federal Trade Commission has created an interactive tool to help mobile health app developers exactly know which federal laws apps will need to follow based on various sets of criteria.

Confirm Patient Profiles and Records Will Match

Data from newly created solutions must flow into existing operational systems.

The ideal fit would be apps or integrations that update patient data for records that are always up to date.

If missed connections occur during system integration, you must talk with the solution provider, and then with a programmer if issues remain.

Watch The Evolving System Trends and Upgrades

To provide the best patient experience, you have to adopt, upgrade and evolve systems at the same rate as users do.

Watch the evolving patient behaviours, and trust in the expertise of your development partners to help guide you in necessary adoption 101.

Keep up with recommended software updates, and read on the latest tech to see new trends coming up. The hottest topics right now, here’s the two being more discussed:

  1. Health Level-7 (HL7) vs Fast Healthcare Interoperability Resources (FHIR): This aims to help your team get collected data in more meaningful ways.
  2. Application Program Interfaces (APIs): APIs help to streamline individual technologies into comprehensive solutions that save time and money.

Clinical Apps Are On Their Way

As the process toward digital data collectors increase and evolve and consumer behaviour becomes more mobile by the day, it’s not very far when apps with clinical setting become widespread as well.

With this, health care systems begin preparing infrastructure for a new techno future, built with regulatory wish and command and the patient experience keeping in top of mind.

We conclude here.

Among several good organizations, CRB Tech Solutions created a good name for itself. We offer good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune.

It has earned a good name for itself among the institute of clinical research in Pune, who offers best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates. For your own career oriented goals, you should join institutes with good clinical research training program.

If you are trying to find clinical research courses in Pune, CRB Tech Solutions is one step ahead from your success.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field

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Inter Sector Collaboration Can Solve Innovation Problems

Inter Sector Collaboration Can Solve Innovation Problems

Collaborations are always good if done with same zeal and on the same subject and in the same direction. David Hytch,Lead Technologist for Offshore Renewables said that during his participation in a challenge translation workshop for the Offshore Wind Innovation Exchange (OWiX) programme, that is run through the Offshore Wind Innovation Hub, itwas carried out to introduce new businesses to the offshore wind supply chain by connecting novel solution providers, from external to the sector, to solve offshore challenges.

Problems often getsolved when seen from a different angle

Solution providers outside of offshore wind sector might have the answer to your problem

Suppose imagine that the glass was an offshore wind turbine and take, for instance, a typical offshore wind problem: that of blade leading edge erosion.

Leading edge erosion causes:

  • aerodynamic loss of functionality
  • expensive repair procedures
  • loss of revenue owing to downtime

If you are from outside the sector, you might well have a solution but tend to ignore the challenges because you are unaware:

  • anything about blades
  • what is a leading edge
  • a concept about aerodynamics

How do you help people solve problems out of their context?

The OWiX programme functions on a simple process:

  1. The owner of the problem chooses two real challenges that would benefit its business if solved
  2. The challenges are converted from an industry specific form to a general challenge
  3. The generic challenges are passed to alternative sectors through a call for ideas
  4. The businesses with the best solutions are given to the problem owners and hence, when there is an opportunity to enter a new supply chain via direct access to the end customer.

There are no odd questions in solving problem

Without several perspectives and approaches in thinking the whole process could not have worked.

  • Is there a data issue?
  • a making issue?
  • a process concern?
  • why you do it that way?

Someone, somewhere already has the answer

The clever part of a process is in the translation of the challenges.

This uses a process which is based on the principles of TRIZ (the theory of inventive problem solving) designed by Genrich Altschuller. He identified five levels of invention:

  1. 32% of inventions are related to knowledge development within an organisation
  2. 45% is related to new knowledge to an industry
  3. 18% related to basic changes within industries
  4. 4% related to new technologies or development of technology
  5. 1% of invention was related to new science

Does that matter?

Hence it means that there is a 99% chance that someone is likely to have a solution to the problem.

We conclude here.

Among several good organizations, CRB Tech Solutions created a good name for itself. We offer good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune.

It has earned a good name for itself among the institute of clinical research in Pune, who offers best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates. For your own career oriented goals, you should join institutes with good clinical research training program.

If you are trying to find clinical research courses in Pune, CRB Tech Solutions is one step ahead from your success.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field

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Good Clinical Practice (GCP) In Clinical Trials

Good Clinical Practice (GCP) In Clinical Trials

In clinical trials you need a scientific quality and an ethical practice to design, run, record and report clinical trials which involve human subjects. There comes GCP in picture.

Companies running a clinical trial must follow certain procedures and practices

Companies undertaking a clinical trial must develop written procedures to implement GCP. Such procedures might include, but not limited to, the following mentioned below:

  • Site selection
  • Document collection for regulatory, review and submission
  • Financial declaration
  • Site initiation
  • Test product distribution and tracking
  • Clinical supervision of test site
  • Reporting safety
  • Audits on quality assurance
  • Necessary documents for study master file and document retention
  • Vendor qualification and oversight (for instance, contract research organization)
  • Compensation and insurance

GCP principles for clinical trials

Some rules and regulations that make up a Good Clinical Practice offer assurance for the protection of rights, safety and well-being of the trial subjects. GCP also assure that the research yields quality scientific data.

Basically a Good Clinical Practice needs the following:

  • Involvement of the local ethics committee(s)
  • Verification of the researcher’s qualifications
  • A study protocol, study brochure, informed consent, and documentation which is essential for undertaking a clinical trial
  • Supervising the clinical trial
  • Report submission and maintenance of records

The core principles of the ICH Good Clinical Practice are mentioned below.

Thirteen core principles of GCP

Ethical principles:  Declaration of Helsinki Clinical trials must be carried out in accordance with the ethical principles that have origin in the Declaration of Helsinki and that are fixed with GCP and applicable regulatory needs.
Benefits against risks Before you start a clinical trial, risks and inconveniences must be measured against the supposed benefit for the individual trial subject and society. A clinical trial must be started only if the anticipated benefits can justify the risks.
Subject’s safety The rights and safety of the trial subjects must be a concern of science and society.
Sufficient supporting data The available non-clinical and clinical information on a test product must be sufficient to support the proposed clinical trials.
Scientifically detailed protocol Clinical trials must be scientifically good and described clearly, in a detailed protocol.
Independent ethics committee supervision A trial must be conducted according to the protocol that has received early approval by institutional review board (IRB)/independent ethics committee (IEC).
Medical care by qualified researcher The medical care offered to subjects, and the medical decisions on their behalf, must always be the responsibility of a qualified doctor.
Qualified professional Each individual in a clinical trial must be qualified by education, experienced and well traed to do their respective task(s).
Informed consent Freely-given informed consent must be obtained from every subject before their participation in a clinical trial.
Records All clinical trial information must be recorded, handled and stored in a way that permit its accurate reporting, interpretation and verification.
Subject confidentiality The confidentiality of records is very essential to respect their privacy.
GMP manufacturing of the investigational product Test products must be produced, handled and stored in according to Good Manufacturing Practice (GMP). They must be used according to the approved protocol.
Quality assurance & supervision Systems with procedures that confirm the quality of every aspect of the clinical trial must be implemented.

The information here is to outline the general processes, principles and concepts of the healthcare product development lifecycle. As the regulatory needs are always changing, it is current as of the date of publication.

We conclude here.

Among several good organizations, CRB Tech Solutions created a good name for itself. We offer good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune.

It has earned a good name for itself among the institute of clinical research in Pune, who offers best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates. For your own career oriented goals, you should join institutes with good clinical research training program.

If you are trying to find clinical research courses in Pune, CRB Tech Solutions is one step ahead from your success.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field

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How an IRT/IWRS Help You In Managing Oncology Trials

Managing Oncology Trials

Oncology Trials, with frequent modifications in doses, several cycle quantities, and other unpredictable factors, continue to pose unique challenges to the work of Clinical Trial Managers or CTM and Clinical Supply Managers or CSM. A flexible IRT/IWRS (Interactive Response Technology/Interactive Web Response System) can offer help in the management of these complex trials.

How to Manage Drug Supply with an Uncertain End of Study Treatment

Unlike other clinical trials which has a fixed duration, oncology trials are often designed to adjust trial duration based on the individual subject’s response as well as overall results across the trial. When selecting an IRT/IWRS service provider, watch for a flexible IWRS/IRT system that can expand the visits for subjects that are eligible for continuous treatment.

By expanding the visit schedule for only those subjects that reaches the end of their present visit schedule, study-wide drug projections are not altered when a single subject reaches the expansion point. This confirms that drug configurations can remain consistent throughout a trial, requiring less intervention whenever a subject’s schedule expands.

Unknown Start and End Dates of Cycles

In situations where treatment cycles might begin earlier or later than expected, an IRT/IWRS with a rigid or static visit routine cannot accommodate shifting visit dates.

Inculcating a system capable of re-projecting a subject’s entire visit schedule after the beginning of each cycle, can address this challenge of scheduling. As subjects might not always come in for their scheduled visit on the expected day for various reasons, like adverse events or personal conflicts, ensure your IRT/IWRS can project future visits based on past ones.

Unscheduled Visits and Dose Withholding

When there is a situation when a subject is not ready to receive their next dose, unscheduled visit and dose withholding capabilities permit you to manage these exceptions in a safe manner.

Dose withholding is created to handle subject safety during the administration of experimental study drugs. This is crucial in oncology clinical trials as subjects are in those situations that could render them sensitive to some treatments.

Dose Modifications in Cycled Visit Schedules

There is a mild balance between changing a patient’s dose to suit their personal needs and managing the clinical trial successfully per the protocol. An IRT/IWRS having the ability to adjust doses based on subject safety and tolerance per the protocol confirms the maximum and minimal dose levels.

To conclude, tracking subject doses might be problematic in oncology clinical trials that consist of various dosing options.

Conclusion: Look into these Challenges

Selecting an IRT/IWRS which is robust enough to handle the unique challenges of oncology trials can help CTMs and CSMs well manage the unexpected. The IRT/IWRS must be able to manage drug supplies with a several study treatment, unknown beginning and end dates of visiting cycles, unscheduled visits and dose withholding, as well as modification of dose in cycled routine visits.

We conclude here.

Among several good organizations, CRB Tech Solutions created a good name for itself. We offer good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune.

It has earned a good name for itself among the institute of clinical research in Pune, who offers best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates. For your own career oriented goals, you should join institutes with good clinical research training program.

If you are trying to find clinical research courses in Pune, CRB Tech Solutions is one step ahead from your success.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field

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Medical Device Jobs And The Various Types

Medical Device Jobs And The Various Types

Medical devices jobs vary a lot as the industry is divided into several categories. There are also several types of medical device companies which include pure-plays, conglomerates and mixed drug-device companies.

Combined drug-device products are medical devices that release a pharma drug, like an asthma pump or insulin pen. Many global pharmas create combined drug-device products which includes Novartis, GSK, and Abbott Laboratories.

The medical devices industry is growing and is driven by innovations and continuous technological developments. The industry of medical device industry can offer opportunities for life science professionals who are currently working or interested in jobs with QC, regulatory affairs, and positions in manufacturing and engineering.

Today’s market full of mobile applications and other electronic devices and are able to provide people with instant health data and analytics. This pressurise the medical devices industry to develop quality-driven healthcare for the masses and maintain high levels of technological inventions. The top medical device companies are Johnson & Johnson, GE, Medtronics, Baxter International Inc. and Siemens Health.

Jobs in medical devices are likewise to that of biotech and pharma sector, but there are some differences which depend on the type of medical device being designed. A number of medical device jobs exist specifically within the industry, mostly surrounding engineering and manufacturing roles.

Here we share an overview of basic roles in medical devices:

Quality assurance (QA) and regulatory affairs

Here you will find QA jobs in medical devices like qualified people, QA officer and QA manager roles. These QA roles have similar responsibilities as that in pharma but adhere to certain guidelines mainly GMP, ISO 13485 and ISO 9000. In this industry, teams of regulatory affairs and QA work closely together, and one person might have several responsibilities.

QA teams ensure that the manufacturing processes outlined by regulatory affairs while trying to gain a licence are strictly followed. Again regulatory affairs in medical devices is similar to pharma but regulatory teams have to work with regulatory agencies, notified bodies and quality guidelines that are specific to medical devices in order to get an approval.

Quality Control (QC)

QC roles are mainly product focused. The QC team confirms that the device, either a surgical instrument or x-ray machine, is of the highest standard. QC scientist and QC analyst are typical roles of jobs in quality control and are mostly in the lab quality testing raw materials or, sometimes, the finished product. QA manager jobs include writing SOPs for those in junior QC positions to follow, as well as confirming quality techniques like HPLC are carried out.

R&D Design

Design engineers, have specific roles in medical devices that are not similar to that in pharma or biotech. Design engineer jobs involve research, to design, test, and modify technical designs for several medical devices before they are prodiced. Sometimes they need to modify the design of the existing devices as well.

Validation

This job has an important aspect of quality assurance across medical devices, pharma and biotech companies. These engineers are responsible for confirming that the making process is checked and confirmed by testing process equipment, like manufacturing machinery and scientific apparatus. They need to check the equipments repeatedly to confirm that it produces the same high-quality product every time.

Manufacturing

Manufacturing roles include manufacturing associate, operator and manufacturing engineer jobs. Manufacturing associates/operator roles have several responsibilities that involve handling machineries for manufacturing, reading and following SOPs, confirming that equipment is clean, and assist in production and packaging. Manufacturing engineer roles are specific as these are the technical people that improve the yielding processes by research, designing, making changes and testing the equipments. These engineers are responsible for assembling the medical devices as well.

Field engineering

They are concerned with the improvement of machine performance and involve installing, support, maintenance and repair of medical device equipment and machineries. They also provide breakdown and support and confirm that health and safety is carried out on-site.

We conclude now.

Among several good organizations, CRB Tech Solutions created a good name for itself. We offer good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune.

It has earned a good name for itself among the institute of clinical research in Pune, who offers best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates. For your own career oriented goals, you should join institutes with good clinical research training program.

If you are trying to find clinical research courses in Pune, CRB Tech Solutions is one step ahead from your success.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field

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Some Clinical Trial Designs To Optimize Patient Involvement

Some Clinical Trial Designs To Optimize Patient Involvement

There are several complexities of clinical research, the expense, difficulties in patient recruitment, adherence, and retention, so a new method is necessary.

Patient recruitment is the biggest hurdle in a clinical trial. Dropouts results in inferior data, lower staff morale, and increased costs.

Patients often face big challenges in taking part in clinical research. In fact, many are not aware that there are clinical trials which seek volunteers.

The fact is that good subjects fear to enrol in a clinical trial owing to negative perceptions. There is somewhat mistrust of industry-funded trials among the public. Patients might need to leave the care of their regular physician which is emotionally traumatic. Once a patient wants to enrol, he must confront the extensive paperwork associated with the informed consent process. These feelings and experiences make things difficult to an already difficult decision.

New clinical trial design models have patient-centricity in built in their design and will be more efficient at organizing, providing pertinent data and patient communication.

  • PCORnet: It was developed by the National Patient-Centered Clinical Research Network. An initiative which uses the vast amount of electronic data present from electronic health records, patient surveys, and shared data from trials, to design and sponsor high priority research. Community involvement is essential to their mission.
  • Crowd sourcing is a practice of getting required services, ideas, or content by requesting contributions from a large group of people, especially an online community, rather than traditional employees or suppliers. Researchers and people can present their protocols to the group for comment. Recruitment happens with referral by interested patients.
  • Clinical Trial Management Software Products. This defines and manages all the activities that happen in a clinical trial process like clinical program or project management, planning of trial and sites, collection of data sets, management of study, protocol and documentation and data analysis.
  • Adaptive trial design is the study where there is a planned opportunity for changes of one or more specified aspects of the study design and hypothesis which is based on analysis of data in a study.
  • Consortiums of competitors are an integration of research professionals from various sectors who were previously competitors. They share financial outlay, patients, and risk along with knowledge, resources and expertise.
  • Explanatory trial design is used to explain trials that aim to assess the efficiencies of an intervention in a well defined and controlled setting.
  • Pragmatic Trial Design is an emerging concept created to assess the effectiveness of interventions in daily life routine practice situations.
  • Qualitative research methods sums up to the understanding of complex social and cultural environments. Qualitative trials has several purposes like deciding the best methods to recruit patients; developing research approaches and equipments; and understanding whether interventions must be implemented, by finding their acceptance to patients and healthcare professionals.
  • Molecular classification. The start of personalized medicine or precision medicine along with updated technologies is helping new trial designs that match patients to the correct genomic- or immune-targeted drugs. This is mainly useful in cancer clinical research as well as targeted diseases where molecular understandings are commonly looked into.

There are almost limitless possibilities for clinical research designs. There is no reason why a study can’t utilize more than one approach. The real challenge is to use technology to improve research and not be run by it.

We conclude now.

Among several good organizations, CRB Tech Solutions created a good name for itself. We offer good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune.

It has earned a good name for itself among the institute of clinical research in Pune, who offers best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates. For your own career oriented goals, you should join institutes with good clinical research training program.

If you are trying to find clinical research courses in Pune, CRB Tech Solutions is one step ahead from your success.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field

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5 Pillars Of Trial Master File Or TMF

5 Pillars Of Trial Master File

To create a strong TMF which is not only ready for inspection, but reliable and good is quite necessary for the remaking of the conduct of a clinical trial during the process of inspection.

Here we list the 5 pillars of TMF that facilitates efficient trial management:

1. Standard processes:

There must be only one way to perform the following tasks:

  • File a TMF document
  • Quality Check a TMF document
  • Quality Check the TMF as a whole

If everyone follows the same standard processes, then there will be lesser space for error.

2. Table of Contents:

To file the documents into the TMF and differentiate one document type from another could be a tricky task. To lower the confusion you need to have a fix table of contents that submitters of document could rely while filing the documents consistently.

3. Metrics and Controls:

Metrics lead to behaviour. There could be nothing more inspiring than viewing your study “with the green” or “with the red” signals.

4. TMF Resources:

From small bio companies to the larger pharmas or CROs, the TMF process will not be a success without proper resources in place. You need the right people. People with an appropriate background and training (a minimum of 2 years of experience in clinical trials is necessary to understand document reconstruction to form a TMF) is needed.

5. eTMF:

The final pillar or foundation for a TMF organization is the application of a sustainable, diverse functional, user-friendly electronic system. Electronic storages not only provide immediate access to the documents, but they might also lower time and enhance perfection of the final study, which could facilitate proper approvals.

To conclude, a well-constructed TMF is a proof that rights and safety of the patients are protected, which in turn will give life-saving treatments to the one who needs them.

We conclude now.

Among several good organizations, CRB Tech Solutions created a good name for itself. We offer good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune.

It has earned a good name for itself among the institute of clinical research in Pune, who offers best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates. For your own career oriented goals, you should join institutes with good clinical research training program.

If you are trying to find clinical research courses in Pune, CRB Tech Solutions is one step ahead from your success.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field

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7 Ethics for Clinical Researchers

It is universally known and worldwide accepted that research and analysis are essential in evolution of human. Clinical Research, is the saviour of the masses in terms of offering protection to health and a cure against many infections.

Clinical trials demands a human volunteer who is willing to be the subject on whom is based the new findings or a medical experiment. Hence consent is necessary from the volunteer before starting the trials. But only acquiring consent is not what required making a clinical research ethical. In consideration of the real values, there are 7 important ethics that every aspirant of a clinical research career must follow.

Wisdom and Knowledge

What a clinical research aims is knowledgeable findings at the conclusion of the research. It is the main responsibility of a CRA or a Clinical Research Associate to make sure an improvement of health or adequate knowledge gain at the end of the research which could help the mankind with respect to health and lifestyle. Hence it is mandatory for a clinical trial professional to have a proper Clinical Research Training before starting a trial.

Scientific validity

Only with consent, a researcher must not test anything which is not scientifically possible. It is unethical in every aspect. A proper and rigorous research must always be the priority for researchers.

Exact Selection of a Subject

Indulging a willing volunteer who’s not much a good subject for the clinical trial is another unethical thing in Clinical Research. Based on scientific objectives and vulnerability, the subject must be selected by a Clinical Research Associate to lower the risks and enhance the benefits.

Ratio of Risk-Benefit

Before finishing a Clinical trial, the ratio of risk and benefits must be assessed by the researcher.  You must follow an optimal clinical research practice and risk avoiding protocols which would help increase the essential benefits and lower the risks in a clinical trial.

Proper Assessment

You must always practice a review of the clinical trial by an individual or a group. Only those unaffiliated reviewers could find the actual benefit and risks of a clinical trial.

Subject must be knowing about the trial

Before gaining consent from an individual to be taken as a subject for a clinical trial, it is essential to educate the volunteer about the nature of the clinical trial and expected possibilities of the research. A voluntary consent only after a complete education about the clinical trial is an ethical practice.

Maintain the Privacy

The subject who would undergo a clinical trial must be protected and their respect must be safeguarded. It is essential to protect the privacy of the subjects involved in the clinical trials and research.

Even if there is the willingness of a subject it is very important to make sure about the above requirements as well.

We conclude here.

Among several good organizations, CRB Tech Solutions created a good name for itself. We offer good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune.

It has earned a good name for itself among the institute of clinical research in Pune, who offers best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates. For your own career oriented goals, you should join institutes with good clinical research training program.

If you are trying to find clinical research courses in Pune, CRB Tech Solutions is one step ahead from your success.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field.

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Ways To Help Patient’s Cope With Situations

Patient’s Cope With Situations

Pharmacists are being said to help promote a new website that aims at helping patients manage their private life while they are incapacitated.

The website is called Gather My Crew and its being launched in the month of July.

It would help friends and family regulate tasks such as meal provision, pet care, child-care, and even dealing with utility providers.

Gather My Crew is the child of its CEO, Dr Susan Palmer, a psychologist who has worked with oncology and palliative care patients and parents of children with by birth genetic illnesses.

She found there she could do very little to help patients if their personal life was chaotic and they were not receiving any help from friends and family.

The website was set up by volunteers and a $200,000 sponsorship from the Melbourne Lord Mayor’s Charitable Fund.

She thinks thousands of people will use it.

Working of the website:

  • The gatherer or the patient, a friend or family member; registers on the website.
  • They choose from more than 80 tasks they need help with.
  • The crew, which comprise of friends, family, neighbours and others, are invited to help via mails.
  • Once the crew accepts an invitation, they check the online calendar and select tasks they could help with.
  • An inner circle could be selected such that sensitive tasks, like changing breast dressings, are done by only those people.
  • If a task isn’t allocated, it’s marked as an urgent one, and a broadcast is sent out to the crew.

Dr Palmer said that about 200 people used the website during a pilot test that started last September.

The volunteers included a young mother coping up with a breast cancer diagnosis, a father hit by a car and parents dealing with premature baby.

Here we conclude now. Hope you find this piece of information helpful. Keep visiting our website to know more about clinical researches trends and findings, worldwide.

In the competition of many organizations, CRB Tech Solutions created a good name. We conduct training classes for jobs with good clinical practice training. CRB Tech has earned the name of one of the best training institute in Pune. It has earned a good name among the institute of clinical research in Pune, in offering the best training in Clinical Research courses.

Clinical research jobs in Pune are increasing and to meet the current demand of proficient candidates, you must join institutes with good clinical research training program. If you are looking for clinical research courses in Pune, CRB Tech Solutions is your one stop towards your career goal.

The Clinical Research review by CRB Tech Solutions is sufficient to make you move ahead in a career in this field.

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Knowing Autism Spectrum Disorder

Knowing Autism Spectrum Disorder

There is no cure till date. The causes are partially understood. And treatments are limited to only tackling symptoms, not the condition.

Autism was once seen separately from other developmental complications like Asperger’s syndrome, pervasive developmental disorders (PDD) and childhood disintegrative disorder. But in 2013, the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, the standard medical reference for mental disorders, merged Asperger’s, PDD and the old definition of autism and created the term autism spectrum disorder.

Several medical professionals and families criticized the change. Though the evidence isn’t removed, there are several anecdotal accounts of some high-functioning patients who met the old, vaguer criteria but not the updated one hence they los medical services associated with autism.

The ASD Rainbow

The autism spectrum explains people with a huge range of developmental disorders. Now, experts use a series of levels to find out where patients lie on the spectrum.

History of Autism

1911 Swiss psychiatrist Eugen Bleuler coins the term autism to describe extreme self-possessiveness and anti-social behaviour in children.

1943 Leo Kanner published the first case studies of autism as a medical condition.

1964 Bernard Rimland publishes the book Infantile Autism: The Syndrome and Its Implications, which says autism is a neurological cause rather and not a psychological one.

1980 The third edition of the Diagnostic and Statistical Manual of Mental Disorders included autism for the first time.

1998 Andrew Wakefield and 12 other researchers published a now-retracted paper in The Lancet linking autism to childhood vaccinations.

2003 Researchers found the first genes linked to autism.

2003 Introduction of an interview process that help physicians and specialists to diagnose the disorder.

2010 The Lancet retracts Wakefield’s paper, and the British Medical Council revokes his medical license. No other research suggested such a link.

2013 The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders merges classic autism, Asperger’s syndrome, childhood disintegrative disorder and PDD under the umbrella of ASD.

Risk Factors

Today, ASD is viewed as the result of genetic and certain environmental factors that influence early brain development.

Genetic

Twin studies are one of the most important evidence for genes being involved [in autism],” says Abha Gupta, a pediatrician who also researches the genetics and neurobiology of ASD at Yale School of Medicine. Since the 1970s, these sorts of studies have revealed that both identical twins are more likely to have autism than both fraternal twins. A recent study has shown that, if one identical twin has ASD, the likelihood of the other twin having it is between 77 and 99 percent; for fraternal twins, the likelihood is 22 to 65 percent.

Hundreds of genes are linked to ASD. Although ASD is inheritable, children with no pedigree of the disorder can yet develop it through genetic mutations. And those who bear kids after they’re 35 years old are more likely to have children with autism.

Environmental

Research is ongoing; some experts believe these factors can influence an infant’s odds of having ASD if they’re exposed to certain things during the early stages of fatal brain development. So far, the only general risk factors accepted are related to maternal health during pregnancy like inflammation stemming from an infection.

Other possible risk factors are premature birth, air and water pollution and pesticides.

No Link Between Vaccinations and Autism

Over the decades, several studies have found no link between autism and childhood vaccinations. Instead, most experts say that Wakefield’s work has set back autism research and created unnecessary fear about childhood vaccinations that yet lingers.

Autism and the Brain

Years of studies suggest that they have an increased brain volume that might correlate with the severity of their symptoms. To mention, the brain returns to normal size, or smaller, by the time a child is an adolescent. Studies have also indicated various brain regions as playing a role in ASD, and that these areas might fluctuate in size compared with brains of kids without ASD, but the work is yet not conclusive.

Treatments

Health professionals can diagnose ASD in kids when they are only 16 months old. This relies on behavioural observations, medical screenings and a child’s history of development. Then, families and doctors work together to come up with a customised treatment plan includes any combination of the following therapies:

Medications

Antipsychotic, anti-anxiety and stimulant medications can, to some degree, control ASD symptoms such as repetitive behaviors, anxiety and irritability. But they also can cause side effects and don’t alleviate anti-social behavior, says Darold Treffert, an autism expert who runs a clinic for children with developmental disorders in Fond du Lac, Wis.

The time will come when we can do a genetic profile to determine the kinds of medications that would be helpful to a patient with autism,” Treffert says.

Behavioral Therapies

Among the many behavioural therapies, the most common is applied behaviour analysis, or ABA.

In ABA sessions, therapists work with children to enhance their behaviour and develop social skills with a combination of techniques, like positive reinforcement and breaking a skill into small chunks so it’s easier to capture.

Therapists also focus more on their personal relationship with their patients. And therapies begin earlier by the age 2 or 3 rather than 7 or 8.

Yet, behavioural therapies remain controversial. Hence, it is said that ASAN recommends programs and services with an aim to help children with autism develop skills that can improve their quality of life, like speech therapy and occupational therapy, which teaches specific daily living skills.

Complementary Therapies

These might reduce a patient’s anxiety, which could also lessen some repetitive behaviours and help in social situations. The most comon are:

  • Pet interaction
  • Fine art and music
  • Dietary programs (vita min/mineral supplements, diets free of yeast, gluten or artificial additive

Here we conclude now. Hope you find this piece of information helpful. Keep visiting our website to know more about clinical researches trends and findings, worldwide.

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