Category Archives: clinical research course

Is Clinical Trial A Product Or A Service?

Is Clinical Trial A Product Or A Service? in a recent ACT ‘What do you think?’ survey, readers were asked if a clinical trial is a service or a product. Only 53% of people identified a clinical trial as a service. Other responses included product (7%), neither (20%), or other (20%) with the most common response in the other category being ‘research.’

These responses are quite typical. There is a lot of confusion within the industry about what the value developed by clinical trials – even till the point of knowing whether a clinical trial is a product or service. This confusion degrades value creation, productivity.
Clinical trials are done to collect data regarding the safety and efficacy of new drug and device designinh. There are many steps and stages of approval in the clinical trials process before a drug or device is out in the consumer market.

Drug and device testing starts with laboratory research which can involve years of experiments in animals and human cells. If the initial lab research is successful, researches send data to the FDA for approval to continue research and testing in humans.

Once getting the approveal, human testing of novel drugs and devices can start and is typically conducted in four phases. Each phase is considered a separate trial and, after completion of the phase, investigators are required to submit their data for approval from the FDA before continuing to the next phase.

Reasons for Conducting Clinical Studies

Basically clinical studies are designed to add to medical knowledge related to the diagnosis, treatment and prevention of diseases or conditions. Some common reasons for conducting clinical studies are:

  • Assessing one or more interventions for treating a disease, syndrome, or condition
  • Finding ways to avoid the initial development or repearation of a disease or condition. These can include medicines, vaccines, or changed in lifestyle , among other approaches.
  • Assessing one or more interventions aimed at identifying or diagnosing a particular disease or condition
  • Examine methods for identifying a condition or the risk factors for that condition
  • Finding and measuring ways to enhance the comfort and quality of life through supportive care for people with a chronic illness

A clinical trial is a service, as the application of knowledge and skills to benefit another entity. The keyfeatures of services are that they involve delivery processes. Products are goods manufactured basically in a yield setting. It is much easier to measure and organise the yield process of products. Service processes are much more difficult to measure and manage.

This doubt about whether a clinical trial is a service or product also results to lower-quality clinical trials and billions of dollars wasted on ineffectual quality improvement investments. Yet, the industry measures trial quality as if it is a product – leading to mismanagement and low-quality trials. The industry has spent billions of dollars trying to improve the quality of trials in the past years without any improvement in reality. The basic reason is that the industry still hasn’t figured out if a clinical trial is a peoduct or a service .

In the race of many institutes CRB Tech Solutions has created its own place. Its known in offering the best training program in Clinical Research. Our clinical research institutes has created a niche for itself in this field.

Clinical research jobs are gaining grounds gradually and to meet the emerging need of good professionals , you should consider upgrading yourself with clinical courses.

Clinical Research review by CRB Tech Solutions will guide you in considering and taking up a clinical research career in this field.

Related Posts:

1) Why Clinical Trials Are Very Much Useful Through Mobiles?

2) Clinical Trials and Its 4 Stages for New Medications

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Apple Plans Transform HealthKit From Tracker To Diagnosis Tool

Apple Plans Transform HealthKit From Tracker to Diagnosis Tool

Till date Apple’s HealthKit has mostly collected fitness data from its devices. In the future, if the company finds its way, the software will interpret that information, converting it into advice for users, doctors and others.

Many health care experts hired by Apple in recent years are designing enhanced electronic health record software that can well analyze and understand the implications of patient data.

The iPhone manufacturer is even working on new apps for the Apple Watch. It can track users’ sleep patterns. Another app focusses on fitness levels by calculating the time taken for the heart rate to fall from its peak to resting level. Apple already has an app that measures heart rate, but yet don’t interpret them.

The ultimate goal of Apple’s health care technology team is to turn HealthKit into a tool that improves diagnoses. The system could do away two problems that plague the field of clinical research and have stumped other specialist firms in the field.

Chief Executive Officer Tim Cook wants Apple to act more in improving software and services to secure new sources of economy and make customers more dependent on the company’s devices.

In early this year, Apple bought Gliimpse Inc., a startup that build software to pull electronic health records from different databases and in different formats and finally store them in one place.

He equated the product to Apple’s music business. That negan with the iPod, but as more people became habituated to storing all their music files digitally, Apple united all music lovers in a single platform on top of the device.

Apple health software might become a revenue driver, too, by keeping people intrigued to the company’s equipments. If a patient’s health records, and related suggestions, are reachable through Apple’s system, it would be difficult to trade in an iPhone for a smartphone running Google’s Android OS, and its health-tracking software Google Fit.

The second module of Apple’s Watch has a built-in GPS tracker, faster processor and is water resistant and many people can run, swim and do other exercise with the device. The upgraded Watch software, dubbed watchOS 3, puts health tracking information more prominently in the user interface, and adds a breathing during exercise app as well as tracking during swimming.

Building more sensors into the Watch serves a limited purpose. The accelerometer can generate most of the useful data needed to monitor a person’s well-being. A glucometer or blood-pressure sensor would only help a small percentage of users, the person said.

Scott Jenkins, said that Apple is working hard with many of these large institutions to produce tools that are medically significant, to take data from sensors.

Stephen Friend, a Merck & Co. veteran who founded health data non-profit Sage Bionetworks, is honored with being the brains behind ResearchKit. He joined Apple as full-time employee in June after working as a consultant for more than two years.

Yoky Matsuoka, formerly technology chief at Google’s Nest Labs unit, joined Apple’s health team last year. Nest mostly known as a hardware specialist, but Matsuoka head the development of software that interpreted and learned from data that its internet-connected thermostats collect.

Apple’s greatest obstacle for now is proving to medical professionals that data delivered from wearables through HealthKit and ResearchKit is reliable.

In the competition of many organizations CRB Tech Solutions developed a big name. Its better known in providing the best training in Clinical Research.

Clinical research jobs are increasing and to meet the increasing requirement of the peofecient professionals , you should consider improving yourself with our clinical research training program.

The Clinical Research review by CRB Tech Solutions will guide you in considering a clinical research career in this field.

Related Topics:

1) Top 10 Clinical Research Companies in Pune

2) Clinical Research Organization

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Digital Health

With digitalization is its development, the field of clinical research introduces a new word to the list. Yes we are talking about Digital health which is the way by which digital and genomic revolutions converging with healthcare and society. Digital health is enabling people to a better track and improve their own and family’s health, live a better life, more productive lives and improve the society.

Now what is the scope of digital health? It has a broad scope that includes health information technology (IT), mobile health (mHealth), wearable devices, telemedicine and telehealth and also personalized medicine.

Other usage of digital health in their efforts to:

  • Lessen inefficiencies,
  • Enhance access,
  • Lessen costs,
  • Improve quality,
  • Make personalized medicine for patients.

Patients and consumers can use digital health to manage and keep a track of their health and wellness related activities.

The use of technologies such as social networks, smart phones and internet applications is not only changing the way we communicate, but is also providing novel ways for us to supervise our health and well-being and giving us greater access to information.

Why is FDA focusing on Digital Health?

Many medical devices now have the ability to connect to and communicate with other systems or devices . FDA approved devices are are being updated to add digital features. New devices that already have these capabilities are now explored.

Many stakeholders are involved in digital health activities, including patients, researchers, health care practitioners, conventional medical device industry firms, and firms new to FDA regulatory requirements, such as mobile application developers.

FDA’s Center for Devices and Radiological Health is overwhelmed about these developments and the combining of medical devices with connectivity and consumer technology. The following are the topics in the field of digital health on which the FDA has been working to provide clarity using practical approaches that balance benefits and risks:

  • Mobile medical apps
  • Wireless Medical Devices
  • Health IT
  • Telemedicine
  • Medical Device Data Systems
  • Medical device Interoperability
  • Software as a Medical Device (SaMD)
  • General Wellness
  • Cybersecurity

How is the FDA developing Digital Health?

CDRH has established the Digital Health Program which tends to protect and promote public health and provide continuous regulatory clarity by:

  • Encouraging collaborations and increasing outreach to digital health customers.
  • Creating and implementing strategies and policies for digital health technologies.

Federal Trade Commission Mobile Health Apps Interactive Tool

If you are designing a mobile health app that collects, creates, or shares consumer information, click on the button to take you to the tool on Federal Trade Commission’s website to find out when FDA, FTC or Office of Civil Rights (OCR) laws apply:

Genomics and Genetics

According to J. Craig Venter, digital health is basically a DNA-driven software device and there is no difference between digital code and genetic code. Digital code is a binary code: 0, 1. while, genetic code is a four-base code: A, C, G, T. There can be no conversion between the two as well as digitized man, as Topol defines it in expanded terms.

Stay connected for more exciting blogs and articles and increase your knowledge with us.

Are you looking for Clinical research course in Pune, then our CRB Tech Solutions would provide with help and support. Its very popular in offering the best training in Clinical Research.

Clinical research jobs are pacing and to meet the emerging need of efficient professionals , you should consider upskill yourself with our institute of clinical research.

Clinical Research review by CRB Tech Solutions can help you in considering a clinical research career in this field.

1)5 Ways ResearchKit Is Revolutionizing Clinical Research

2)Crowd funding In Clinical Research

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Stem Cells Therapy- A Hope For Parkinson’s Cure

Parkinsosn’s disease affects the middle aged people and what to be known is that exercise in middle age can prevent the occurrence. Many clinical trials are being carried out to find a definite cure to the condition. One among them is stem cells therapy which seems very promising.

In this blog we narrate the ordeal of a 59 year old man who lived with Parkinson’s disease(PD) for 12 years. Ashok Kumar formerly served as a general manager in a private firm, had been leaving an active and productive life until he was diagnosed with PD. This progressive neurological disorder brought his life to a halt and then followed years of futile treatment and he started losing hope. But then his decision of undergoing stem cell therapy for PD turned out to be one of the most favorable decisions of his life.

Talking about his dilemma , Kumar said that he couldn’t stand, sit or walk. He would fall forward and his body suffered from tremors, postural instability and rigidity. When he was at the verge of giving up his hope of recovery, then Plexus Neuro and Stem Cell Research Centre reignited new hope in his life. The stem cell therapy was initiated and within four months his speech, posture, writing ability and body balance improved a lot and he no longer had to take any medications for PD.

Dr Naeem Sadiq, neurologist and director of Plexus Neuro and Stem Cell Research Centre said Kumar is one of the many Parkinson’s patients who have got successfully treated at the center. They have 25 years of clinical experience in treating neurological disorders and provides stem cell therapy for neurological, orthopaedic and psychiatric disorders and several other incurable diseases.

In the early times, medications and certain surgical procedures were the only treatments available for PD. Though medications is less effective in the long-term and might cause side-effects, surgery is not always feasible or goos choice.

In recent years, application of stem cell therapy for treating PD has become a boon for the patients. Stem cells are like mother cells which originate from the developing embryo and differentiate into different types of cells. They are also named progenitor cells as they create new cells. Dr Sadiq said that in stem cell therapy for Parkinson’s disease, stem cells are collected from the patient’s own bone marrow. The cells are isolated and after lab quality analysis, the isolated stem cells are transplanted into the patient’s body. The stem cells migrate to the affected area of the brain, get attached there and transform themselves into healthy tissue and hence replace the damaged cells.

After this procedure the patient is discharged the next day. Regular follow-ups are important and based on the severity of disease, a patient might need subsequent doses of stem cell transplant. In case of Kumar, two doses of stem cell transplant in four months period worked effectively said Dr Sadiq.

Later stages of Parkinson’s are highly debilitating. With the progress of the disease, dopamine producing brain cells get lost in the substantia nigra region of the brain. Dopamine, a brain chemical that plays key role in regulating coordination and movement of the body. Till date, the exact reason behind the loss of dopamine cells in PD is not well clear.

Early detection and timely treatment of PD is crucial for positive treatment outcomes. The general public lacks awareness of PD. The initial stage of PD usually begins as mild tremors on one side of the body which is either neglected by patients or misdiagnosed.

If you are looking for Clinical research course in Pune, then CRB Tech Solutions would provide with proper guidance. Its one of the best in offering training in Clinical Research.

Clinical research jobs are increasing fast and to meet the requirement of efficient professionals , you should consider improving yourself with our institute of clinical research.

This Clinical Research review will help you in considering a clinical research career in the field.

Related Topics:

1)5 Ways ResearchKit Is Revolutionizing Clinical Research

2)Crowd funding In Clinical Research

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Clinical Research For Physiotherapy

Clinical research is quite vital in the field of physiotherapy. Physiotherapists depends on information from researches to enhance the knowledge they have already gained through their university education and with continuous education courses.

Physiotherapists use the method of “evidence-based practice” as the basis for their treatments; based on quality controlled scientific research and clinical reasoning. Clinical research helps the practitioners keep updated with the latest in practice methods. With the knowledge gained from clinical research, the physiotherapists can explain that the methods CR specialists use to treat our patients are based on empirical evidence, peer review and sound clinical reasonings behind every principles.

There is a great deal of clinical research being performed in physiotherapy nowadays as has been the case for many decades. By regularly update of skills and taking on broad new proof based research, physiotherapists are at the cutting edge of developments in the healthcare sector and the physiotherapist have the scientific evidence to support their treatment methods.

As physiotherapists, they treat a wide array of medical conditions :

  • Spinal pain and injuries
  • Headaches
  • Sports injuries
  • Fractures
  • Musculoskeletal problems
  • Post-surgical rehabilitation
  • Biomechanical problems
  • Arthritic conditions
  • Neurological disorders and diseases
  • Cardiothoracic conditions
  • Paediatric conditions

A few to mention!

Physiotherapists are trained in manual therapy which means they are “hands on” with their patients. In addition to their manual skills they sometimes make use of different ways to reduce pain and inflammation including ice, hot packs,TENS, E-stim, laser treatment and ultrasound. Trigger point therapy and acupuncture is widely practiced by physiotherapists. The physiotherapy experts are highly trained in exercise prescription and often give their patients exercises to practice at home to help resolve their conditions.

The profession addresses neurological,orthopedic and cardiopulmonary problems among people of various age range from infants, children, adults and all populations.

Physiotherapy treatment might involve exercise to improve strength,

motion and endurance range and to correct imbalance of posture and muscle , joint mobilization, manipulation and soft tissue massage, as well as stretching and trigger point therapy to reduce stiffness and to relieve pain.

Patients with neurological disorders such as multiple sclerosis, stroke, cerebral palsy, Parkinson’s disease and spinal cord injury that can benefit greatly with physiotherapy methods. Interventions focus on muscle control, recovery of fine and gross motor skills, improve daily function, regaining of strength and flexibility, restoring and improving gait and training in the use of aids of mobility.

Cardiopulmonary conditions respond good to physiotherapy intervention. Patients who have difficulty performing their activities of daily living, or who have problem with shortness of breath and reduced endurance, can achieve improved quality of life through guided training. Intervention includes manual therapy and exercise to help clear congestion in the lungs, counseling about risk factors, patient education to prevent future occurrence and behavior modification. For those patients who have had cardiopulmonary surgery, physiotherapy is initiated at an early stage to prevent the patient from losing strength and function.

So the clinical trials that are ongoing worldwide, would definitely help with many novel techniques that would be more efficient, patient friendly and less time consuming.

Amidst many institutes in Pune, CRB Tech Solutions has created its own niche. Its very popular in giving the best training in Clinical Research. Our clinical research institute has created a name for itself in this field.

Clinical research jobs in Pune are increasing gradually and to meet the emerging need of efficient professionals , you should consider upskill yourself with our clinical courses.

The Clinical Research review by CRB Tech Solutions will help you in considering and taking up a clinical research career in this field.

Related Posts:

1) Clinical Research Organization

2) What is Clinical Research Organization and jobs in a CRO

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Research Areas in the Clinical Psychology

Clinical psychology research is very significant to the nation’s health and well being as other clinical research. It works in the same way as the same way as clinical scientists try to understand the prevention and spread of different genetic and infectious diseases, scientists conduct rigorous psychological research studies to comprehend , prevent, and treat the human condition as it applies psychologically to individuals,families and diverse communities.

Factual results gathered from psychological research studies help practitioners in developing effective interventions and techniques that clinical physicians execute proven, reliable results that improve lives, help troubled relationships, help addicts, and help manage and treat a variety of other mental health issues.

In order to evaluate this body of research, clinical psychology students must undergo proper clinical research training to make significant professional contributions to the field , staying current and up-to-date with the research taking place at universities and research labs across the world. Doing research, investigating unique ways to understand the human mind, and finding solutions to enrich the lives of all others.

Most of these research studies basically fall within one of three main areas integral to clinical psychology:

Assessment

An important aspect of clinical psychology research, involves assessment – or producing significant and reliable tests. Assessments take the form of written tests e.g. intelligence tests, vocational tests and other tests created to measure aptitude for specific careers, interests, and personality types.

Clinical psychologists interview individuals, review their medical data, and conduct clinical trials as part of the assessment process. A comprehensive assessment approach confirms that psychologists apply the most effective and appropriate psychological treatments and interventions.

Roberts and Hardi stated that measurement of treatment procedures, treatment integrity, behavioral changes, functional performance, objective measurements, change of perceptions, and satisfaction from a variety of sources, follow-up assessment, etc., are needed to finalize the ‘scientific credentials’ of each therapeutic approach.

Diagnosis

After gathering sufficient data, they consult the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-R), which lists criteria and generalized definitions for mental illnesses and conditions. Categories of symptoms differentiate one mental illness from another, and the basic course of each illness.

Beyond the DSM-IV-R, however, research in the field of diagnosing mental health problems remains one of the most exciting research areas in the field today – thanks to rapid advances in technology. Numerous techniques of brain imaging that map brain structure and function now give researchers “images” of both normal and unusual brain functioning. Scientists are using CT, MRI and PET to come up with greater accuracy in diagnosing various mental illnesses.

Psychotherapies

A set of procedures or techniques that psychological problems, and come up with different ways of thinking, behaving, or feeling – has exploded in popularity since the middle of the last century. Most psychotherapies come within one of the four main psychotherapeutic frameworks:

Psychodynamic Therapy

Psychodynamic therapy discovers an individual’s unconscious, seeking reasons or explanations for the individual’s present behavior. This treatment, also called insight-oriented therapy, attempts to bring underlying factors grounded in beginning life to the individual’s attention, increasing self-awareness and self-understanding.

Psychodynamic therapy originates from Sigmund Freud’s psychoanalysis, making it the most old form of psychotherapy. As a result, a large body of research exists to either help or refute the effectiveness of this approach.

Because the results of psychoanalysis research are difficult to measure than behavioral-oriented therapies, research methodologies and outcomes of treatment have been questioned – especially those of the previous studies.

Psychodynamic therapy requires long-term treatment, sometimes a year or more, also complexing the research process. However, researchers today apply the most rigorous scientific processes, including statistics studies completed over a number of years, to study of efficacy of psychodynamic practice and techniques, and many studies report significant positive outcomes.

In the race of many institutes CRB Tech Solutions has created its own niche. Its very popular in offering the best training in Clinical Research. Our clinical research institute has created a niche for itself in this field.

Clinical research jobs are increasing gradually and to meet the emerging need of efficient professionals , you should consider upgrading yourself with clinical courses.

The Clinical Research review by CRB Tech Solutions will support and guide you in considering and taking up a clinical research career in this field.

Related Topics:

1) Pharmacovigilance: Common terms used in drug safety

2) Pharmacovigilance scope

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A Drought in Antibiotic Discovery

A Drought in Antibiotic Discovery

The year 1928 saw a major medical breakthrough owing to Flemming’s serendipitous discovery of penicillin, which was later claimed as the 20th century miracle drug. But the impact of this discovery was not well understood until the 1940s, when its application as a therapeutic agent was made possible by Florey and Chain.

Blamed for this late realization was the lack of biochemical and microbiological expertise at that time, as well as the lack of interest and support from the scientific community brought about by previous experience with the failure of pyocyanase and the toxicity of Salvarsan.

A-Drought-in-Antibiotic-Discovery

In 1935, a breakthrough that covered the era of antibacterials was made by the German biochemist Gerhard Domagk at the Bayer Laboratories of the I.G. Farben company in Germany. He discovered and developed the first sulfonamide, a synthetic red dye popularly known by its trade name of Prontosil, the first commercially available antibacterial.

The clinical successes resulted in a sharp decline in mortality due to killer diseases such as meningitis, child bed fever and pneumonia. Domagk’s discovery saved many lives, including prominent figures such as Winston Churchill and Franklin D. Roosevelt, Jr., son of then US President Roosevelt.

Inspired by the groundbreaking work of Domagk and Fleming, Florey and Chain, a number of subsequent antimicrobial discoveries quickly followed. Nowadays, newer antimicrobial compounds continue to be discovered and introduced, although the rate has slowed considerably.

According to an analysis done by a known magazine, large pharma companies spend approximately $5 billion to bring one new drug to market. About $350 million of the cost is to bring the drug to market, the rest is the money spent on drugs that fail safety or efficacy clinical trials, thus a pharma company must recoup the billions that they lose on failed drugs by the one drug that makes it to market.

A lot of money spent and pharmaceutical companies recoup more of their money on drugs like antidepressants and anti-inflammatories because they can be used regularly and not lose their effectiveness. That is not the case with antibiotics.

Antibiotics are very costly to develop and they can lose their power to fight infections with time. How? The bacterium that survived and is antibiotic-resistant is the one that begins reproducing in the body, thus the antibiotic originally used is no longer effective and a new antibiotic is needed to fight the mutated bacteria.

In the past five years the FDA has approved two systemic antibiotics. This is a drop of 88% since the mid-1980s.

While the benefits of the GAIN act are great, it seems that there is still a steady decline of new antibiotic development that has worried many institutions and organizations such as the World Health Organization (WHO) which stated that we’re in a competition against time to develop new antibacterials.

The small biotechnology companies are bringing new antibiotics to the market and it appears that the Center for Disease Control is pushing hospitals to enact antibiotic stewardship programs to make sure that such medicines are only used when they are really required. Dr. Tom Frieden of the CDC stated that antibiotic prescription can save patients’ from deadly infections and protect lifesaving remedies for tomorrow’s patients.”

Clinical research jobs are increasing and to meet the increasing need of efficient professionals , you should consider excelling yourself with training in Clinical Research

This Clinical Research review by CRB Tech Solutions will help you in taking a clinical research career in this field.

Related Topics:

1) Pharmacovigilance: Common terms used in drug safety

2) Pharmacovigilance scope

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Lazy Ways to be Healthy

Lazy Ways to be Healthy Being healthy could be a huge challenge, especially if you don’t have the time or the energy. But with some small changes to your life where you can improve your health and yet be lazy. Eat differently, exercise just a little bit more, and make a few other small changes to your life to improve your health without not making huge changes to your everyday life.

Lazy-Ways-to-be-Healthy

Eating and living healthier are great things to be doing, but what if it just seems like so much work. What about those who are lazy? Any hope?

Yessss!

Now eating only fruits and vegetables, looks so monotonous. Every time you need to eat and do things like wash grapes and cut celery. Spend the $6 on some reusable plastic containers or bags and in a few minutes you can wash, chop and package in bulk. You’re left with per-portioned snacks that take no work other than grabbing them from the fridge and opening the container.

As any coffee addict will say, coffee can cure many illness, but do you know it can also help to burn more fat in a workout. Studies reveal that a cup of black coffee before exercise can open the gates for your body to use more fat cells as energy. Bonus lazy points: use a coffee maker with a clock on it so it’s already brewed and waiting for you when you wake up in the morning.

Do you remember childhood days when your mom would make you layout your clothes for school the night before? Scientifically not related though. But good old mom was a bit of genius. By putting your gym clothes out the night before it saves time by cutting out searching through drawers and it removes the excuse to stay in bed because your gear is already laid out and waiting. It’s a small way to encourage yourself onto that treadmill. Well to step that laziness up to expert level you can sleep in your workout clothes.

Having insomnia? You might be too hot. Not the hotness which could rund in your mind; we are talking about heat. Reports say that you can promote better sleep by turning the thermostat down to 65 degrees Fahrenheit (that’s approximately 18 degrees Celsius for our friends outside the US). So, switch on that A/C and grab a blanket because you are heading for a great night’s sleep or a great afternoon’s nap.

Get a pet to improve your health

If you want big health results without any big effort, getting a pet could be a wise way out. Multiple researches have shown that pet owners have improved physical and mental health, including lowered BP, better ability to cope with adverse life effects, and lowered stress levels.

Exercise while watching TV

Vegging out in front of the TV set is the quickest way to pile on the pounds. However, to boost your fitness while watching TV, try squeezing a mini-workout into each commercial break. You can try from push ups to skipping or a jogging , there are plenty of measures to introduce activity into your TV-watching schedule.

So, now you’ve seen some excellent ways to be healthy even when you’re lazy! If you’ve got more excellent ideas leave a comment below. In the competition of many institutes CRB Tech Solutions created a unique name. Its well known in offering the best training in Clinical Research.

Clinical research jobs are rapidly increasing and to meet the increasing need of efficient professionals , you should think about improving yourself with our clinical research institute.

This Clinical Research review by CRB Tech Solutions will guide you in considering a clinical research career in this field.

Related Posts:

1) What is Clinical Research Organization and jobs in a CRO
2) Pharmacovigilance (GpvP) Training

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Hormone Therapy Side Effects And Management

Hormone Therapy Side Effects And Management are as follows

What Is Hormone Therapy

Hormone therapy is gaining grounds in the are of clinical research , Hormone therapy or hormonal therapy is the usage of hormones in medical treatment. Treatment with hormone antagonists might also be referred to as hormonal therapy or anti hormone therapy.

The general classes of hormone therapy are carcinogenic hormone therapy and hormone replacement therapy, of which there are various kinds (e.g., for menopause,wither male of female or for sex change).

Hormone therapy is a type of systemic therapy that functions to add, block or remove hormones from the body to slow or halt the growth of cancer cells. At Cancer Treatment Centers of America (CTCA), they use hormone therapy to fight various forms of cancer alongside Integrative Oncology Services to fight the side effects.

Hormones are the body’s chemical messengers and are produced in the endocrine glands, which include glands such as the pancreas, thyroid, ovaries in women and testicles in men. Hormones can influence the growth of some cancers, such as breast and prostate. But, in some cases, they can kill, slow or halt the growth of cancer cells.

Hormone therapy generally involves taking medicines that prevent cancer cells from getting the growth hormones. In some cases, the physician may surgically remove the gland responsible for hormone production. The physicians may use hormone therapy in combination with other cancer treatments, such as chemo and radiation therapy.

CTCA clinicians work in concert to give all possible treatment options. The care team would consider hormone therapy as a treatment option if one is diagnosed with breast, prostate, ovarian or thyroid cancers. Several factors influence the type of hormone therapy one might receive, including the age, type and size of the tumor, and the presence of any hormone receptors on the tumor.

Patients are at the center of treatment decisions at CTCA. They understand there are many factors that might influence the treatment option they choose, such as any desire to have children. They listens to the patients and work as a team to develop a treatment plan that could meet individual needs.

General side effects of hormone therapy

The side effects might depend on the type of hormone therapy being administered. Only generalized side effects are mentioned here. More information about the side effects of specific hormone therapies can be obtained in the specific drugs section.

General side effects include

  • Tiredness
  • Digestive system problems
  • Menopausal symptoms
  • Hair thinning
  • Effects on your muscles and bones
  • Weight gain
  • Headaches
  • Memory problems
  • Mood swings and depression
  • Blood clots

Side effects management

Some hormone therapies can cause many side effects, depending on the type of cancer involved. For example, breast cancer patients may experience dryness and irritation, hot flashes, vaginal discharge, decreased sex drive; and mood changes.

Prostate cancer patients might experience reduced ability to achieve an erection or orgasm. Aromatase inhibitors also can cause joint and muscle pain, and an increased risk of bone thinning i.e. osteoporosis.

Throughout the entire treatment, the patient would be provided integrative oncology services to help combat these side effects. Nutrition therapy,naturopathic medicine,mind-body medicine and spiritual support can help reduce side effects, as well as improve the overall quality of life.

In the race of many institutes CRB Tech Solutions has created its own name. Its very popular in offering the best training in Clinical Research. Our clinical research institute has created a niche for itself in this field.

Clinical research jobs are increasing gradually and to meet the emerging need of efficient professionals , you should consider upgrading yourself with clinical courses.

The Clinical Research Review by CRB Tech Solutions will help and guide you in considering and taking up a clinical research career in this field.

Related Posts:

1. How Clinical Research Management Can Help You?

2. 5 Clinical Management Factors to be Discussed

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New Study Raises Doubts Over Heart Stem Cell Therapy Benefits

New Study Raises Doubts Over Heart Stem Cell Therapy Benefits Science and findings many times don’t have a concluding phase. And the same goes with the heart stem cell theory. Numerous clinical trials have been attempted to test the benefits of using a patient’s own stem cells to treat heart disease. Results have been very conflicting; some claim real improvements in heart function, whilst others report none.

A group at Imperial College London investigated the possible reasons for this disparities and found strange but unexplained discrepancies within reports of many of the clinical trials.

Results:

- 133 reports of 49 clinical trials were investigated
– 600+ inconsistencies were found
– Disparities ranged from minor to serious mistakes and wrong data
– Reports with the most faults claimed most benefit to patients, while those without showed no improvement in patients’ health

Idea behind the study

Improvement in heart function is mainly measured by the increase of ejection fraction (EF). Bone marrow stem cells have been widely studied as a powerful therapeutic for patients who have suffered heart failure or heart attack. Stem cells are taken from the patient’s own bone marrow and after treatment transplanted into the heart. This is an autologous therapy; Some claim real improvements whereas others report no improvement at all.

Improvement in heart function is routinely calculated by the increase of ejection fraction (EF) In 2013, researchers from the National Heart and Lung Institute at Imperial College London analyzed 5 ground-breaking clinical trials. Each report on these trials claimed positive results for patients but numerous unexplained disparities were discovered. These findings prompted a deeper investigation by the DAMASCENE . Their aim was to find whether discrepancies in clinical trial methodologies and reporting are the reason for the mixed reported effects of this therapy.

What did this study reveal?

Clinical trials with more discrepancies in their reports also appeared to depict more effect of the treatment on patients. Discrepancies in trial reports were identified using meta-analysis. Its a statistical method used to compare results from different studies and by regression; measuring the results of each study based on the number of patients in the trial. In this way, the various sizes of the trials were taken into account; results from a trial of 100 patients would be considered double as influential as a trial with 50 patients.

This therapy is at the latent stage and is not a routine treatment for patients. Previously this therapy has been stated as safe, but more than 40 discrepancies have now been discovered in the reports from a clinical trial that tested safety. Although the main focus of this study was on discrepancies and their relationship to effectiveness of the treatment, separate issues were identified in some trials which suggest that well being should also be further investigated.

The results from this study on early phase trials suggest that it is not clear whether this therapy is effective in the treating heart disease. Clinical trial reports free from identifiable mistakes could be considered the most reliable but these have shown no positive effects in patient’s conditions. Two international phase III clinical trials have started recruiting participants in Europe and will focus on the efficacy of utilizing stem cells from the bone marrow to treat heart patients. However, if the findings from this new statistical study are correct, many previous clinical research reports could now be considered unreliable. This raises doubts over autologous bone marrow stem cell therapy as a valid powerful treatment for heart disease.

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