Burn & Pain Management Clinical Research

Today in this article we shall talk about acute burn and pain management clinical research which is becoming an emerging model to solve challenges in burn and pain trial designs. We know that burns cause severe pain and burning sensation and very less trial have been consucted in this field.

Major developments have enhanced management of severe pain all over the globe. Emphasis on acute pain studies have shifted to outcomes which go beyond good pain relief towards lowering in the risk of developing chronic pain, critical medical conditions, and the development of psychological disturbances due to pain. Anyways, burn-associated pain represents one area where there is very less direction on the appropriate way and type of pain that patients experience. To overcome challenges in burn pain management research trials, there are various design-important issues that must be considered.

Understanding Variability of Burn Pain

In any trial model, neuroscience clinical researchers must consider the many attributes that affect the burn pain, including the phase of the wound and degree of the burn, the person, depth of the skin burnt, and the inflammatory response. A dynamic approach to burnt pain and trauma management is critical for a successful clinical outcome and must consider all of the above variables in targeting the various patient populations. To say that the pain is homogeneous among all patient phenotypes will lead to insufficient pain assessment, which barriers meaningful research and prevents optimal management of burn pain.

Human Pain Models

In the process of pain management studies, the selection of human pain models has many essential implications, and that permeates from early to late development. Most of the time, the main factor in selection of a pain model is what the indication will be at the end of the trial. Interestingly, a small number of proven models, such as osteoarthritis and diabetic neuropathy are typically chosen, hence limiting the development of new therapeutics for many other indications.

One approach could be to conduct trials with lesser studied models, like burn pain, which is very severe in case of deep and extensive burns, and mainly treated with standard analgesics such as opioids. This is clearly an area which would benefit from the development of new therapeutics, and although like every clinical trial model it has several challenges, it also presents itself as relatively straight forward, from the prospective of selection criteria. Clearly, the clinical trial faced on a daily basis is complex and burn pain management research is requiredto continue developing solutions to solve the clinical problems. To aid early analgesic development, human experimental pain models are receiving deserved attention and would inform later stages, including burn pain, more appropriately. 

To know more about Human Experimental Pain Models, check out various webinars available online. Several on-webinar are hosted by Worldwide on this topic. You could also learn more about Worldwide’s analgesia and pain experience by checking their sites, and read an elaborate article on burn pain trial design in their site.

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