Monthly Archives: June 2014

Clinical research in mind body medicine

Mind-body medicine

Mind body medicine as the name itself says both mind and body are interconnected health of the mind depends on the health of the body and vice versa. But generally mind is the initiator for health. The healing power within us is more than enough for us to get well and to be fit. A sound mind has a sound body so think well and that is what you are and a sound body has a sound mind so exercise yourself to be fit and fine internally and externally.

“The power is yours and the choice is yours!”

Ancient mind body medicine

The ancient mind body medicine was and is ayurveda which says that there is a link between body and mind. But the current day medicine suggests that mind and body re two different aspects.

People with rheumatoid arthritis added fuel to the fire were depressed. The reason is everything is in the mind, changing the attitude, changes the world. The new field was called psychoneuroimmunology (“psycho” for psychology; “neuro” for neurology, or nervous system; and “immunology” for immunity).

Meditation could affect blood pressure. More understanding of the mind-body link came in 1975, It is said that mental and emotional cues could affect the immune system.

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 Mind-body techniques

Focus on what you want rather than what you don’t want.

Biofeedback: it is an amazing technique generally used of controlling involuntary actions such as lowering heart beat. It is most often used to treat tension headache, migraine headache, and chronic pain.

Cognitive behavioral therapy: this technique is about getting present to what is the barrier in our mind may be a fear or any other negative thought. So auto suggestions and positive thoughts are of great help.

 

Relaxation techniques: There are 3 major types of relaxation techniques:

Autogenic training: it is all about creative visualization considering yourself in the place where you want to be and imagining and dreaming about it as if you are in the present and have such feelings and take actions until it gets manifest in physical reality.

Progressive muscle relaxation: it is all about tensing each and every part of your body one by one starting from toe and reaching your head part.

Meditation: You might be knowing about meditative techniques focusing on the same thought or on your breathing or on a single spot or repeating any mantra  by following  a deity.

Hypnosis: when human body relaxes and when the conscious and the subconscious mind are totally connected and is receptive of any kind of thoughts and suggestion. A hypnotherapist will help you out with positive thoughts and suggestion say if you are a person having phobia then by suggestion you will become courageous and empowering.

Workability

mind body medicine works if you believe it works. He is able to if he believes he is able to In 1989, for example, a clinical study at Stanford University School of Medicine demonstrated the power of the mind to heal. Of 86 women with late stage breast cancer, half received standard medical care while the other half received standard care plus weekly support sessions. In these sessions, the women were able to share both their grief and their triumphs. It was discovered that the women who participated in the social support group lived twice as long as the women who did not.

Mind-body medicine good for:

  • Cancer
  • High blood pressure
  • Asthma
  • Coronary heart disease
  • Obesity
  • Pain and nausea/vomiting related to chemotherapy
  • Insomnia
  • Diabetes
  • Stomach and intestinal problems (including indigestion, irritable bowel syndrome, constipation, diarrhea, ulcerative colitis, heartburn, and Crohn’s disease)
  • Fibromyalgia
  • Menopausal symptoms such as hot flashes, depression, and irritability
  • Mental health issues, such as anxiety and depression
  • In an analysis of mind-body studies, researchers found that cognitive behavioral therapy is the most long lasting treatment for tinnitus (ringing in the ears). Relaxation techniques, hypnosis, and biofeedback also helped. Some researchers believe that chronic fatigue syndrome, which affects the immune system, can be treated with mind-body medicine.

Any precautions:

Mind-body medicine should not make you feel that your attitude is the cause of your illness. Mind-body medicine is generally very safe and works well when combined with usual medical care. Each mind-body technique may have its own risks and side effects. Talk with your health care provider about any concerns you may have.

“The word has health has the word heal in it”

 

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Clinical Research for ayurveda- crb tech

Clinical Research for ayurveda

However advanced the technology may be in terms of  English medicines but the source of medicinal herbs and ayurveda are the best and will never lose its importance. There are different origins for medicines like animals, plants, mineral, metal etc for different countries. As said earlier in the current scenario due to the advanced medicinal value in English the olden golden technology is reducing its usage. There has been a massive contribution of good health from ayurveda.

It is recommended by the herbal/traditional remedies in national healthcare programs in view of their low cost and better safety profiles along with people’s faith in such remedies by the World Health Organization. However standardization of the quality of drug is an ongoing process. It includes the identification of plants, good agricultural practices including cultivation, post-harvesting technology, storage precautions for raw material, manufacturing process with analytical profiles, shelf-life of products and pharmacopoeial standards of quality control.

Quantitative fingerprint of major components would be much appreciated; it is initiated by High Performance Thin Layer Chromatography (HPTLC) or Liquid Chromatography – Mass Spectrometry (LC-MS). There are many things to be followed like analysis for microbial contamination, pesticide residues and heavy metals for estimating with regards to their permissible levels. Final touch after touch after all these aspects, the herb is subjected for evaluation of its activity through experimental pharmacology including toxicity studies. Once the herb is screened by these tests, it is evaluated for documentation of clinical pharmacological data which is then followed by clinical studies (Phase – 1 to Phase – 3).

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Ten point examination for initiating the execution of therapeutics suggested by charaka are

  • Kaarana (cause – physician)
  • Karana (instrument – drug)
  • Karyayoni (source of action – Dhatu Vaishamyata)
  • Karya (action)
  • Karyaphala (fruits/results of action)
  • Anubandha (longevity)
  • Desha (land/patient)
  • Kaala (time/seasons and state of the patient)
  • Pravritti (initiation)
  • Upaya (means of action)

 

It is further said that the ten fold examination such as Prakriti (nature), Guna (qualities), Prabhava (specific factor), Jaatam (place of growth), Ritu (season for collection), Grihitam (mode of collection), Nihitam (methods of preservation), Upaskritam (method of processing), Matra (dosage) and Yukti (judgment about patient and vitiated Doshas or application of intelligence for evaluating vitiated Doshas and subsiding them).

And examination of patients is done by tenfold examination with reference to Prakriti (constitution), Vikriti (morbidity), Sara (excellence of Dhatus), Samhanana (compactness of the body), Pramana (measurement of organs of the body), Satmya (homologation), Satva (psychic state), Aharashakti (power of intake and digestion of food), Vyayamashakti (power of performing physical actions) and Vaya (age).

 

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Clinical research Placebo effect

Clinical research Placebo effect

There are various kinds of medication and a medication may have several effects on a patient. Sometimes patients given a placebo treatment will have a perceived or actual improvement in a medical condition, a phenomenon commonly called the placebo effect. It can be observed when an inactive substance is usually administered. Is it new to hear? Will it be effective in terms of clinical trials for Parkinson’s disease?

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The word placebo takes its root from a Latin word “placere” means, “to please.” It is a very passive treatment. After the administration of the placebo technique on the subject it will be observed inactively. Expectation of benefit is the main cause of benefit in both active as well as inactive treatments. It can also show its traces by mere interaction with doctors or any health provider. There may also be beneficial effects of additional treatment or improved care provided during a clinical trial of a new medication.

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In the context of a clinical trial of new medications, the term “placebo effect” sometimes refers to any improvement in symptoms experienced by the control group. In addition to expectation of benefit, other contributors to this improvement in patients’ symptom scores may include the tendency for patients to be coachable enough when their symptoms are worse, and “bias” in the rater’s scoring of patients’ symptoms. The beneficiary community will be empowering enough in terms of their health after undergoing a treatment. There has been improvement for the symptoms of asthma and stomach pain.

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Expectation of the benefit will alone speak for the welfare of the patients or else it will be another normal medication technique. Another example was for retinal operation where only anesthesia was used and from patient’s side only expectation was required.

The placebo effect can introspect with the assessment of whether a new medication or treatment has genuine benefit. Placebo is used as a base for comparison for any newly launched medication technique. Rather than clinical trial it can be called as a placebo- controlled trial. When the destination of the treatment is unknown it is called as “double-blind.” When the subjects are assigned to active treatment or placebo groups by chance, this is called a randomized trial.

Randomized, double blind, placebo-controlled trials offer the most phenomenal way to control for the placebo effect and have become the “top notch” in clinical trial design for scrutiny of new drugs or other treatments. For a new medication or therapy to be considered effective, it must all the three steps and should score more than a placebo in a double-blind, randomized, placebo-controlled trial (sometimes the comparison is made to another active treatment, instead of placebo). Sometimes therapies that are thought to be effective are no better than placebo when tested in this type of trial.

Within 6 months of time long lasting effect has been seen in Parkinson’s disease with the use of placebo effect. Similarly, improvement and deterioration in Parkinson’s disease patients have been observed after the introduction and discontinuation, respectively, of placebo medication. Placebo effects appear to be particularly evident in the clinical trials of surgical therapies.

Similarly, 30% improvement in motor scores in the placebo (imitation surgery) control patients was observed in the double-blind trial of porcine mesencephalic tissue in Parkinson’s patients. And here the improvement s has been shown within 18 months this shows that clinical trials for placebo effect was nor effective than another normal medication treatment

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This suggests that the improvement in motor function that is observed in the placebo groups of clinical trials in Parkinson’s disease patients might be due, in part, to actual physiological changes in the damaged brain dopamine nerve cells.

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Watch out for Apple I-Watch

Watch out for Apple I-Watch

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Well an apple app in a way keeps new fascinating ways ahead. There are many products of apple like I-pad air, I-pad mini with retina display, I-phone, AirPort Express, Apple keyboard, I-Mac, Mac Book Air, Mac Book Pro, Magic Track pad,

Apple Battery Charger, Apple Tv, I-Pod classic, I-Pod nano, I-Pod shuffle, I-Pod touch, I-Tunes. Now please watch out for Apple I-Watch

With the theme around wearable technology this year, our research has revealed more data points with respect to Apple’s  I-Watch  and the production of certain I-Watch components is scheduled to begin later this month and there are plans for a sharp acceleration into fall and it is expected that I-Watch to be released along with the I-Phone6 in September. So watch out for Apple I-watch

I-Watch will function as an intermediate device to Apple’s I-Phone. It is going to be a new IOS interactive notifications feature and the overall enhanced connectivity between devices that has been revealed at its Worldwide Developers Conference and it has been appearing that Apple’s view is supported and an expected wearable tech device.

It can also be said that I-Watch would is going to be very easily affordable for Apple users. And there is going to be a price band for the I-Watch (similar to other Apple products), and the starting price could be $199-229, it might be a marketing strategy for making it very competitive with other brand-name smart watches on the market and consumers can consume it by staying in their comfort zone.

Well there are some models of the I-Watch which are as cheap as $200, there are indications that premium models of the device could be offered at different price ranges.

The existence of an I-Watch or any other wrist-worn device is yet to confirm by Apple but there have been several scintillating hints that suggest an entry of smart phone from I-Phone.

There is one thing to note before making such a bold prediction about the arrival of the I-Watch and the upcoming I-Phone. And the research is revealing more evidence that the 5.5-inch I-Phone 6 will launch very soon.  There has been an awesome report that Apple’s I-Phone 6 would be available in two larger screen sizes of 4.7 inches and 5.5 inches.

It is going to be a massive hit and mass production of the screen from July through until September and the target is two million units in total, according to the report. And the display will measure 1.52-inches. In terms of the glass, it will be P-OLED or plastic OLED. So watch out for Apple I-watch coming soon J

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What is so big about the big data?

What is so big about the big data?

1. Ocean of Data

There are 2.5 quintillion bytes of data created per day my goodness! And you know what 90% of the data in the world today has been created in the last two years alone. Well if you look at the source of data it is actually everywhere:  gathering climate information, digital pictures and videos, purchase transaction records, post to social media  and cell phone GPS signals to name a few.

2. Big Data Generates Jobs

There is millions of IT jobs going to be generated to support big data by 2015, and in United States it is going to be 1.9 million job vacancies. Every big data job will be having at least 3 people outside of IT so in that way we can foresee 6 million jobs generated by the information economy. It is so big about the big data

3. Plan your work your plan

IT leaders and professionals believe that there is lack of workers with the skill required to plan, execute and take advantage of the potential of their organization’s data assets.  Big data projects might mean relooking job roles and titles, as well as

the non-technical skills needed to make the best use of the data. It is so big about the big data

4. Information versus Data

TCS had a look up at the number of companies having proper information or structured data versus data or unstructured data. A much higher than expected percentage of data was not structured – either unstructured or semi-structured and a little less than a quarter of the data were external. It is so big about the big data

5. Negligible big data challenge

There will not big talents to deal with the much sophisticated Big Data. There will be a shortage in United States alone of about two lakh people with deep analytical skills as well as 1.5 million managers and analysts will know the usage of analysis of big data to make effective decisions.

6. Big data Big demand

High tech, telecommunications, travel-related, and banking are the most spending industries; life sciences, retail, and energy/resources companies spend the least

7. Data Quality

The owner of the data is not known by most of the IT professionals and IT leaders. When the data is orphan or unknown of it parent then there comes a question of who will take up the responsibility of the quality of the data. As data integration is necessary it is to be ensured that the quality is awesome.

8. Disparate Systems

IT leaders and IT professionals claim their data is stored in disparate systems – and these organizations must build new platforms to accommodate these increased data management needs.

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